{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T21:51:49Z","timestamp":1686606709692},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: A significant issue in stem cell therapy is to understand the role of this type of cell in the tissue regeneration. To explain this mechanism, an experimental study has quantified that the bone marrow cell transplantation decreases the number of inflammatory cells and reduces the fibrosis area in chagasic mice. Using this experimental data, we have developed an agent-based computational model to investigate the regeneration of the chronic chagasic cardiomyopathy after bone marrow stem cell transplantation.<\/jats:p>\n               <jats:p>Results: Our model includes six different types of agents: inflammatory cell, fibrosis area, cardiomyocyte, proinflammatory cytokine tumor necrosis factor-\u03b1, Trypanosoma cruzi parasite and bone marrow stem cell. This latter promotes apoptosis in inflammatory cells, reduction in the fibrosis area and can differentiate into cardiomyocyte. Proinflammatory cytokine tumor necrosis factor-\u03b1 can increase the fibrosis area and T.cruzi can increase the number of inflammatory cells. Our results for both apoptosis of inflammatory cells and reduction in the fibrosis area were compared with experimental data. They suggest that the concentration pattern is the most important factor to characterize the kinetics of cardiac tissue regeneration after bone marrow stem cell transplantation.<\/jats:p>\n               <jats:p>Availability: The source code of our software is available online at www.vivas.ufba.br\/bone\/bone.zip<\/jats:p>\n               <jats:p>Contact: \u00a0vivianegalvao@uefs.br<\/jats:p>\n               <jats:p>Supplementaty information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn362","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T00:25:07Z","timestamp":1216340707000},"page":"2051-2056","source":"Crossref","is-referenced-by-count":15,"title":["Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation"],"prefix":"10.1093","volume":"24","author":[{"given":"Viviane","family":"Galv\u00e3o","sequence":"first","affiliation":[{"name":"1 Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Feira de Santana, 44031-460, Feira de Santana \u2013 BA, 2Centro de Pesquisa Gon\u00e7alo Moniz \u2013 Fiocruz, 40296-710 and 3Instituto de F\u00edsica, Universidade Federal da Bahia, 40210-340, Salvador \u2013 BA, Brazil"},{"name":"1 Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Feira de Santana, 44031-460, Feira de Santana \u2013 BA, 2Centro de Pesquisa Gon\u00e7alo Moniz \u2013 Fiocruz, 40296-710 and 3Instituto de F\u00edsica, Universidade Federal da Bahia, 40210-340, Salvador \u2013 BA, Brazil"}]},{"given":"Jos\u00e9 Garcia Vivas","family":"Miranda","sequence":"additional","affiliation":[{"name":"1 Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Feira de Santana, 44031-460, Feira de Santana \u2013 BA, 2Centro de Pesquisa Gon\u00e7alo Moniz \u2013 Fiocruz, 40296-710 and 3Instituto de F\u00edsica, Universidade Federal da Bahia, 40210-340, Salvador \u2013 BA, Brazil"}]},{"given":"Ricardo","family":"Ribeiro-dos-Santos","sequence":"additional","affiliation":[{"name":"1 Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Estadual de Feira de Santana, 44031-460, Feira de Santana \u2013 BA, 2Centro de Pesquisa Gon\u00e7alo Moniz \u2013 Fiocruz, 40296-710 and 3Instituto de F\u00edsica, Universidade Federal da Bahia, 40210-340, Salvador \u2013 BA, Brazil"}]}],"member":"286","published-online":{"date-parts":[[2008,7,17]]},"reference":[{"key":"2023020211095752200_B1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nrmicro1249","article-title":"The Trypanosoma cruzi\u2013host-cell interplay: location, invasion, retention","volume":"3","author":"Andrade","year":"2005","journal-title":"Nat. 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