{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:52:44Z","timestamp":1771476764254,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Blogo is a web-based tool that detects and displays statistically significant position-specific sequence bias with reduced background noise. The over-represented and under-represented symbols in a particular position are shown above and below the zero line. When the sequences are in open reading frames, the background frequency of nucleotides could be calculated separately for the three positions of a codon, thus greatly reducing the background noise. The \u03c72-test or Fisher's exact test is used to evaluate the statistical significance of every symbol in every position and only those that are significant are highlighted in the resulting logo. The perl source code of the program is freely available and can be run locally.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/acephpx.cropdb.org\/blogo\/, http:\/\/www.bioinformatics.org\/blogo\/<\/jats:p>\n               <jats:p>Contact: \u00a0lwcbio@yahoo.com.cn; xnwang@21cn.net<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available atBioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn407","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T03:29:13Z","timestamp":1217993353000},"page":"2254-2255","source":"Crossref","is-referenced-by-count":14,"title":["BLogo: a tool for visualization of bias in biological sequences"],"prefix":"10.1093","volume":"24","author":[{"given":"Wencheng","family":"Li","sequence":"first","affiliation":[{"name":"1 School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510641, 2National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, 3College of Light Industry and Food Sciences, Key Lab of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510641, China and 4Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6139, South Africa"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"1 School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510641, 2National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, 3College of Light Industry and Food Sciences, Key Lab of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510641, China and 4Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6139, South Africa"}]},{"given":"Shaoguang","family":"Liang","sequence":"additional","affiliation":[{"name":"1 School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510641, 2National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, 3College of Light Industry and Food Sciences, Key Lab of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510641, China and 4Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6139, South Africa"}]},{"given":"Yonghua","family":"Wang","sequence":"additional","affiliation":[{"name":"1 School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510641, 2National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, 3College of Light Industry and Food Sciences, Key Lab of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510641, China and 4Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6139, South Africa"}]},{"given":"Chris","family":"Whiteley","sequence":"additional","affiliation":[{"name":"1 School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510641, 2National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, 3College of Light Industry and Food Sciences, Key Lab of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510641, China and 4Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6139, South Africa"}]},{"given":"Yicheng","family":"Cao","sequence":"additional","affiliation":[{"name":"1 School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510641, 2National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, 3College of Light Industry and Food Sciences, Key Lab of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510641, China and 4Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6139, South Africa"}]},{"given":"Xiaoning","family":"Wang","sequence":"additional","affiliation":[{"name":"1 School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510641, 2National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, 3College of Light Industry and Food Sciences, Key Lab of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510641, China and 4Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6139, South Africa"}]}],"member":"286","published-online":{"date-parts":[[2008,6,4]]},"reference":[{"key":"2023020211251098600_B1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.849004","article-title":"WebLogo: a sequence logo 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Theor. Biol"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/24\/19\/2254\/49051609\/bioinformatics_24_19_2254.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/24\/19\/2254\/49051609\/bioinformatics_24_19_2254.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T13:56:53Z","timestamp":1675346213000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/24\/19\/2254\/247631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,4]]},"references-count":7,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2008,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btn407","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2008,10,1]]},"published":{"date-parts":[[2008,6,4]]}}}