{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:15:15Z","timestamp":1784967315136,"version":"3.55.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2955,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Many non-synonymous single nucleotide polymor-phisms (nsSNPs) in humans are suspected to impact protein function. Here, we present a publicly available server implementation of the method SNAP (screening for non-acceptable polymorphisms) that predicts the functional effects of single amino acid substitutions. SNAP identifies over 80% of the non-neutral mutations at 77% accuracy and over 76% of the neutral mutations at 80% accuracy at its default threshold. Each prediction is associated with a reliability index that correlates with accuracy and thereby enables experimentalists to zoom into the most promising predictions.<\/jats:p>\n               <jats:p>Availability: Web-server: http:\/\/www.rostlab.org\/services\/SNAP; downloadable program available upon request.<\/jats:p>\n               <jats:p>Contact: \u00a0bromberg@rostlab.org<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn435","type":"journal-article","created":{"date-parts":[[2008,8,31]],"date-time":"2008-08-31T00:13:58Z","timestamp":1220141638000},"page":"2397-2398","source":"Crossref","is-referenced-by-count":240,"title":["SNAP predicts effect of mutations on protein function"],"prefix":"10.1093","volume":"24","author":[{"given":"Yana","family":"Bromberg","sequence":"first","affiliation":[{"name":"1 Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, 2Columbia University Center for Computational Biology and Bioinformatics (C2B2) and 3NorthEast Structural Genomics Consortium (NESG) and New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, 1130 St Nicholas Ave. Rm. 802, New York, NY 10032, USA"},{"name":"1 Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, 2Columbia University Center for Computational Biology and Bioinformatics (C2B2) and 3NorthEast Structural Genomics Consortium (NESG) and New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, 1130 St Nicholas Ave. Rm. 802, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Yachdav","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, 2Columbia University Center for Computational Biology and Bioinformatics (C2B2) and 3NorthEast Structural Genomics Consortium (NESG) and New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, 1130 St Nicholas Ave. Rm. 802, New York, NY 10032, USA"},{"name":"1 Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, 2Columbia University Center for Computational Biology and Bioinformatics (C2B2) and 3NorthEast Structural Genomics Consortium (NESG) and New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, 1130 St Nicholas Ave. Rm. 802, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Rost","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, 2Columbia University Center for Computational Biology and Bioinformatics (C2B2) and 3NorthEast Structural Genomics Consortium (NESG) and New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, 1130 St Nicholas Ave. Rm. 802, New York, NY 10032, USA"},{"name":"1 Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, 2Columbia University Center for Computational Biology and Bioinformatics (C2B2) and 3NorthEast Structural Genomics Consortium (NESG) and New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, 1130 St Nicholas Ave. Rm. 802, New York, NY 10032, USA"},{"name":"1 Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, 2Columbia University Center for Computational Biology and Bioinformatics (C2B2) and 3NorthEast Structural Genomics Consortium (NESG) and New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, 1130 St Nicholas Ave. Rm. 802, New York, NY 10032, 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