{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T20:39:16Z","timestamp":1676320756527},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"21","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2951,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Recent studies have revealed that alternative splicing plays an important role in the observed protein and interaction diversity. Special microarrays allow for measuring gene expression at the exon level and thus for studying alternative transcripts and their corresponding protein domain architecture. We have developed the Cytoscape plugin DomainGraph that enables the visualization and detailed study of domain\u2013domain interactions forming protein interaction networks. In addition, the integration of exon expression data supports the analysis of alternative splicing events and the characterization of their effects on the protein and domain interaction network. Different expression patterns between human tissues or cells can be identified by comparing the generated domain graphs.<\/jats:p>\n               <jats:p>Availability: The plugin DomainGraph and the online documentation are available at http:\/\/domaingraph.bioinf.mpi-inf.mpg.de.<\/jats:p>\n               <jats:p>Contact: \u00a0mario.albrecht@mpi-inf.mpg.de<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn437","type":"journal-article","created":{"date-parts":[[2008,8,19]],"date-time":"2008-08-19T00:14:03Z","timestamp":1219104843000},"page":"2546-2548","source":"Crossref","is-referenced-by-count":6,"title":["Integrating expression data with domain interaction networks"],"prefix":"10.1093","volume":"24","author":[{"given":"Dorothea","family":"Emig","sequence":"first","affiliation":[{"name":"1 Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Campus E1.4, 66123 Saarbr\u00fccken, Germany and 2Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA"}]},{"given":"Melissa S.","family":"Cline","sequence":"additional","affiliation":[{"name":"1 Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Campus E1.4, 66123 Saarbr\u00fccken, Germany and 2Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA"}]},{"given":"Thomas","family":"Lengauer","sequence":"additional","affiliation":[{"name":"1 Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Campus E1.4, 66123 Saarbr\u00fccken, Germany and 2Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA"}]},{"given":"Mario","family":"Albrecht","sequence":"additional","affiliation":[{"name":"1 Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Campus E1.4, 66123 Saarbr\u00fccken, Germany and 2Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA"}]}],"member":"286","published-online":{"date-parts":[[2008,9,3]]},"reference":[{"key":"2023020211372738100_B1","doi-asserted-by":"crossref","first-page":"ii220","DOI":"10.1093\/bioinformatics\/bti1135","article-title":"Decomposing protein networks into domain-domain interactions","volume":"21","author":"Albrecht","year":"2005","journal-title":"Bioinformatics"},{"key":"2023020211372738100_B2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2006.06.023","article-title":"Alternative splicing: new insights from global analyses","volume":"126","author":"Blencowe","year":"2006","journal-title":"Cell"},{"key":"2023020211372738100_B3","doi-asserted-by":"crossref","first-page":"R64","DOI":"10.1186\/gb-2007-8-4-r64","article-title":"Discovery of tissue-specific exons using comprehensive human exon microarrays","volume":"8","author":"Clark","year":"2007","journal-title":"Genome Biol."},{"key":"2023020211372738100_B4","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/nprot.2007.324","article-title":"Integration of biological networks and gene expression data using Cytoscape","volume":"2","author":"Cline","year":"2007","journal-title":"Nat. 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Proteome Res."},{"key":"2023020211372738100_B10","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/bioinformatics\/btm012","article-title":"Functional evaluation of domain-domain interactions and human protein interaction networks","volume":"23","author":"Schlicker","year":"2007","journal-title":"Bioinformatics"},{"key":"2023020211372738100_B11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2004.10.022","article-title":"Function of alternative splicing","volume":"344","author":"Stamm","year":"2005","journal-title":"Gene"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/24\/21\/2546\/49055357\/bioinformatics_24_21_2546.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/24\/21\/2546\/49055357\/bioinformatics_24_21_2546.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T14:33:52Z","timestamp":1675348432000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/24\/21\/2546\/191044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,3]]},"references-count":11,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2008,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btn437","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2008,11,1]]},"published":{"date-parts":[[2008,9,3]]}}}