{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:34:31Z","timestamp":1775129671963,"version":"3.50.1"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Investigation of transcription factors (TFs) and their downstream regulated genes (targets) is a significant issue in post-genome era, which can provide a brand new vision for some vital biological process. However, information of TFs and their targets in mammalian is far from sufficient. Here, we developed an integrated TF platform (ITFP), which included abundant TFs and their targets of mammalian. In current release, ITFP includes 4105 putative TFs and 69 496 potential TF-target pairs for human, 3134 putative TFs and 37 040 potential TF-target pairs for mouse, and 1114 putative TFs and 18 055 potential TF-target pairs for rat. In short, ITFP will serve as an important resource for the research community of transcription and provide strong support for regulatory network study.<\/jats:p>\n               <jats:p>Availability: ITFP can be accessed at http:\/\/itfp.biosino.org\/itfp<\/jats:p>\n               <jats:p>Contact: \u00a0yyzhu@fudan.edu.cn; yxli@sibs.ac.cn<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn439","type":"journal-article","created":{"date-parts":[[2008,8,20]],"date-time":"2008-08-20T02:49:03Z","timestamp":1219200543000},"page":"2416-2417","source":"Crossref","is-referenced-by-count":143,"title":["ITFP: an integrated platform of mammalian transcription factors"],"prefix":"10.1093","volume":"24","author":[{"given":"Guangyong","family":"Zheng","sequence":"first","affiliation":[{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"},{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"},{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Tu","sequence":"additional","affiliation":[{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"},{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Xiong","sequence":"additional","affiliation":[{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaochun","family":"Wei","sequence":"additional","affiliation":[{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"},{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Xie","sequence":"additional","affiliation":[{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyong","family":"Zhu","sequence":"additional","affiliation":[{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"},{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixue","family":"Li","sequence":"additional","affiliation":[{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"},{"name":"1 School of Life Sciences, Fudan University, Shanghai 200433, 2Department of Computing and Information Technology, Fudan University, Shanghai 20043, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 4Graduate School of the Chinese Academy of Sciences, Beijing 100039, 5College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240 and 6Shanghai Center for Bioinformation Technology, Shanghai 200235, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,8,19]]},"reference":[{"key":"2023020211252061100_B1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/ng1532","article-title":"Reverse engineering of regulatory networks in human B cells","volume":"37","author":"Basso","year":"2005","journal-title":"Nat. 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