{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:19:13Z","timestamp":1791220753382,"version":"4.1.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: We describe here an exploratory tool, called FunNet, which implements an original systems biology approach, aiming to improve the biological relevance of the modular interaction patterns identified in transcriptional co-expression networks. A suitable analytical model, involving two abstraction layers, has been devised to relate expression profiles to the knowledge on transcripts\u2019 biological roles, extracted from genomic databases, into a comprehensive exploratory framework. This approach has been implemented into a user-friendly web tool to promote its open use by the community.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.funnet.info<\/jats:p>\n               <jats:p>Contact: \u00a0edi.prifti@crc.jussieu.fr<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn492","type":"journal-article","created":{"date-parts":[[2008,9,18]],"date-time":"2008-09-18T00:25:03Z","timestamp":1221697503000},"page":"2636-2638","source":"Crossref","is-referenced-by-count":72,"title":["FunNet: an integrative tool for exploring transcriptional interactions"],"prefix":"10.1093","volume":"24","author":[{"given":"Edi","family":"Prifti","sequence":"first","affiliation":[{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UR G\u00e9odes, Centre IRD de l'Ile de France, Bondy F-93143 and 4Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition and Endocrinology department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UR G\u00e9odes, Centre IRD de l'Ile de France, Bondy F-93143 and 4Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition and Endocrinology department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UR G\u00e9odes, Centre IRD de l'Ile de France, Bondy F-93143 and 4Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition and Endocrinology department, Paris F-75013, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Daniel","family":"Zucker","sequence":"additional","affiliation":[{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UR G\u00e9odes, Centre IRD de l'Ile de France, Bondy F-93143 and 4Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition and Endocrinology department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UR G\u00e9odes, Centre IRD de l'Ile de France, Bondy F-93143 and 4Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition and Endocrinology department, Paris F-75013, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Clement","sequence":"additional","affiliation":[{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UR G\u00e9odes, Centre IRD de l'Ile de France, Bondy F-93143 and 4Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition and Endocrinology department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UR G\u00e9odes, Centre IRD de l'Ile de France, Bondy F-93143 and 4Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition and Endocrinology department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 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