{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:07:39Z","timestamp":1763366859562},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2915,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Profile Comparer (PRC) is a stand-alone program for scoring and aligning profile hidden Markov models (HMMs) of protein families. PRC can read models produced by SAM and HMMER, two popular profile HMM packages, as well as PSI-BLAST checkpoint files. This application note provides a brief description of the profile\u2013profile algorithm used by PRC.<\/jats:p>\n               <jats:p>Availability: The C source code licensed under the GNU General Public Licence and Linux and Mac OS X binaries can be downloaded from http:\/\/supfam.org\/PRC.<\/jats:p>\n               <jats:p>Contact: \u00a0martin.madera@gmail.com<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn504","type":"journal-article","created":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T00:34:47Z","timestamp":1223598887000},"page":"2630-2631","source":"Crossref","is-referenced-by-count":78,"title":["Profile Comparer: a program for scoring and aligning profile hidden Markov models"],"prefix":"10.1093","volume":"24","author":[{"given":"Martin","family":"Madera","sequence":"first","affiliation":[{"name":"Department of Computer Science, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"2023020212224821400_B1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023020212224821400_B2","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511790492","volume-title":"Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids","author":"Durbin","year":"1998"},{"key":"2023020212224821400_B3","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/bioinformatics\/14.9.755","article-title":"Profile hidden Markov models","volume":"14","author":"Eddy","year":"1998","journal-title":"Bioinformatics"},{"key":"2023020212224821400_B4","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1006\/jmbi.2001.5080","article-title":"Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure","volume":"313","author":"Gough","year":"2001","journal-title":"J. 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