{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:59:15Z","timestamp":1780408755606,"version":"3.54.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2894,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Motivation: In most quantitative trait locus (QTL) mapping studies, phenotypes are assumed to follow normal distributions. Deviations from this assumption may affect the accuracy of QTL detection and lead to detection of spurious QTLs. To improve the robustness of QTL mapping methods, we replaced the normal distribution for residuals in multiple interacting QTL models with the normal\/independent distributions that are a class of symmetric and long-tailed distributions and are able to accommodate residual outliers. Subsequently, we developed a Bayesian robust analysis strategy for dissecting genetic architecture of quantitative traits and for mapping genome-wide interacting QTLs in line crosses.<\/jats:p><jats:p>Results: Through computer simulations, we showed that our strategy had a similar power for QTL detection compared with traditional methods assuming normal-distributed traits, but had a substantially increased power for non-normal phenotypes. When this strategy was applied to a group of traits associated with physical\/chemical characteristics and quality in rice, more main and epistatic QTLs were detected than traditional Bayesian model analyses under the normal assumption.<\/jats:p><jats:p>Contact: \u00a0runqingyang@sjtu.edu.cn; dengh@umkc.edu<\/jats:p><jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn558","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T00:34:37Z","timestamp":1225413277000},"page":"1033-1039","source":"Crossref","is-referenced-by-count":9,"title":["Bayesian robust analysis for genetic architecture of quantitative traits"],"prefix":"10.1093","volume":"25","author":[{"given":"Runqing","family":"Yang","sequence":"first","affiliation":[{"name":"1 School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, People's Republic of China and 2School of Medicine, University of Missouri\u2014Kansas City, Kansas City, MO 64108, USA"},{"name":"1 School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, People's Republic of China and 2School of Medicine, University of Missouri\u2014Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"1 School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, People's Republic of China and 2School of Medicine, University of Missouri\u2014Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"1 School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, People's Republic of China and 2School of Medicine, University of Missouri\u2014Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwen","family":"Deng","sequence":"additional","affiliation":[{"name":"1 School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, People's Republic of China and 2School of Medicine, University of Missouri\u2014Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,10,30]]},"reference":[{"key":"2023051607024622000_B1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.2517-6161.1974.tb00989.x","article-title":"Scale mixtures of normal distributions","volume":"36","author":"Andrews","year":"1974","journal-title":"J. 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