{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:19:23Z","timestamp":1773818363892,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Although genetic association studies often test multiple, related phenotypes, few formal multivariate tests of association are available. We describe a test of association that can be efficiently applied to large population-based designs.<\/jats:p>\n               <jats:p>Availability: A C++ implementation can be obtained from the authors.<\/jats:p>\n               <jats:p>Contact: \u00a0manuel.ferreira@qimr.edu.au<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary figures are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn563","type":"journal-article","created":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T01:14:11Z","timestamp":1227143651000},"page":"132-133","source":"Crossref","is-referenced-by-count":204,"title":["A multivariate test of association"],"prefix":"10.1093","volume":"25","author":[{"given":"Manuel A. R.","family":"Ferreira","sequence":"first","affiliation":[{"name":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"},{"name":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"},{"name":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"},{"name":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"},{"name":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"}]},{"given":"Shaun M.","family":"Purcell","sequence":"additional","affiliation":[{"name":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"},{"name":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"},{"name":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"},{"name":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"},{"name":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"},{"name":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, 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