{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:32:44Z","timestamp":1762623164656},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: FAMHAP is an established software for haplotype association analysis of nuclear families. We have released a major update that comprises various new features for case-control data. Furthermore, weprovide an additional program runFamhap that allows users to start the same method repeatedly for varying sets of genetic markers. In addition, a platform-independent graphical user interface (GUI) was developed to simplify the usage of both FAMHAP and runFamhap. The runFamhap program greatly facilitates the application of FAMHAP to genome-wide association studies (GWAS) and supports flexible genome-wide haplotype analysis. As an example, we describe application to HapMap data.<\/jats:p>\n               <jats:p>Availability: The software is available at http:\/\/famhap.meb.uni-bonn.de<\/jats:p>\n               <jats:p>Contact: \u00a0herold@imbie.meb.uni-bonn.de; becker@imbie.meb.uni-bonn.de<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn581","type":"journal-article","created":{"date-parts":[[2008,11,11]],"date-time":"2008-11-11T01:24:01Z","timestamp":1226366641000},"page":"134-136","source":"Crossref","is-referenced-by-count":57,"title":["Genetic association analysis with FAMHAP: a major program update"],"prefix":"10.1093","volume":"25","author":[{"given":"Christine","family":"Herold","sequence":"first","affiliation":[{"name":"Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany"}]},{"given":"Tim","family":"Becker","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany"}]}],"member":"286","published-online":{"date-parts":[[2008,11,9]]},"reference":[{"key":"2023013110022738100_B1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2307\/3001775","article-title":"Tests for linear trends in proportions and frequencies","volume":"11","author":"Armitage","year":"1955","journal-title":"Biometrics"},{"key":"2023013110022738100_B2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/gepi.10323","article-title":"Maximum-likelihood estimation of haplotype frequencies in nuclear families","volume":"27","author":"Becker","year":"2004","journal-title":"Genet. 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