{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:27:06Z","timestamp":1779118026229,"version":"3.51.4"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size.<\/jats:p>\n               <jats:p>Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy.<\/jats:p>\n               <jats:p>Availability: \u00a0www.broad.mit.edu\/ultrasome.<\/jats:p>\n               <jats:p>Contact: \u00a0bnilsson@broad.mit.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp091","type":"journal-article","created":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T01:44:06Z","timestamp":1235094246000},"page":"1078-1079","source":"Crossref","is-referenced-by-count":18,"title":["Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution"],"prefix":"10.1093","volume":"25","author":[{"given":"Bj\u00f6rn","family":"Nilsson","sequence":"first","affiliation":[{"name":"1 Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA, 2Department of Hematology and Transfusion Medicine, Lund University Hospital, SE-221 85 Lund, Sweden, 3Hematology Division, Brigham and Women's Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA and 4Department of Automatic Control, Royal Institute of Technology, SE-100 44 Stockholm, Sweden"},{"name":"1 Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA, 2Department of Hematology and Transfusion Medicine, Lund University Hospital, SE-221 85 Lund, Sweden, 3Hematology Division, Brigham and Women's Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA and 4Department of Automatic Control, Royal Institute of Technology, SE-100 44 Stockholm, Sweden"},{"name":"1 Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA, 2Department of Hematology and Transfusion Medicine, Lund University Hospital, SE-221 85 Lund, Sweden, 3Hematology Division, Brigham and Women's Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA and 4Department of Automatic Control, Royal Institute of Technology, SE-100 44 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Johansson","sequence":"additional","affiliation":[{"name":"1 Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA, 2Department of Hematology and Transfusion Medicine, Lund University Hospital, SE-221 85 Lund, Sweden, 3Hematology Division, Brigham and Women's Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA and 4Department of Automatic Control, Royal Institute of Technology, SE-100 44 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Al-Shahrour","sequence":"additional","affiliation":[{"name":"1 Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA, 2Department of Hematology and Transfusion Medicine, Lund University Hospital, SE-221 85 Lund, Sweden, 3Hematology Division, Brigham and Women's Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA and 4Department of Automatic Control, Royal Institute of Technology, SE-100 44 Stockholm, Sweden"},{"name":"1 Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA, 2Department of Hematology and Transfusion Medicine, Lund University Hospital, SE-221 85 Lund, Sweden, 3Hematology Division, Brigham and Women's Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA and 4Department of Automatic Control, Royal Institute of Technology, SE-100 44 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"1 Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA, 2Department of Hematology and Transfusion Medicine, Lund University Hospital, SE-221 85 Lund, Sweden, 3Hematology Division, Brigham and Women's Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA and 4Department of Automatic Control, Royal Institute of Technology, SE-100 44 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin L.","family":"Ebert","sequence":"additional","affiliation":[{"name":"1 Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA, 2Department of Hematology and Transfusion Medicine, Lund University Hospital, SE-221 85 Lund, Sweden, 3Hematology Division, Brigham and Women's Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA and 4Department of Automatic Control, Royal Institute of Technology, SE-100 44 Stockholm, Sweden"},{"name":"1 Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA, 2Department of Hematology and Transfusion Medicine, Lund University Hospital, SE-221 85 Lund, Sweden, 3Hematology Division, Brigham and Women's Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA and 4Department of Automatic Control, Royal Institute of Technology, SE-100 44 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