{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:46:06Z","timestamp":1773391566290,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Annotation tools help scientists to traverse the gap between characterized and uncharacterized proteins. Tools for the prediction of protein function include those which predict the function of entire proteins or complexes, those annotating functional domains and those which predict specific residues within the domain. We have developed WSsas, a web service focused on the annotation of essential functional residues. WSsas uses similarity searches and pairwise alignments to transfer functional information about binding, catalytic and protein\u2013protein interaction residues from solved structures to query sequences. In addition, WSsas can supply information about the relevant functional atoms. The web service definition (WSDL) file and a Perl client are freely available at http:\/\/www.ebi.ac.uk\/thornton-srv\/databases\/WSsas\/.<\/jats:p>\n               <jats:p>Contact: \u00a0talavera@ebi.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp116","type":"journal-article","created":{"date-parts":[[2009,2,28]],"date-time":"2009-02-28T01:55:53Z","timestamp":1235786153000},"page":"1192-1194","source":"Crossref","is-referenced-by-count":17,"title":["WSsas: a web service for the annotation of functional residues through structural homologues"],"prefix":"10.1093","volume":"25","author":[{"given":"David","family":"Talavera","sequence":"first","affiliation":[{"name":"EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]},{"given":"Roman A.","family":"Laskowski","sequence":"additional","affiliation":[{"name":"EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]},{"given":"Janet M.","family":"Thornton","sequence":"additional","affiliation":[{"name":"EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]}],"member":"286","published-online":{"date-parts":[[2009,2,27]]},"reference":[{"key":"2023013110282363800_B1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2023013110282363800_B2","doi-asserted-by":"crossref","first-page":"W362","DOI":"10.1093\/nar\/gkl124","article-title":"ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins","volume":"34","author":"de Castro","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2023013110282363800_B3","article-title":"Architectural styles and the design of network-based software architectures","volume-title":"PhD Thesis.","author":"Fielding","year":"2000"},{"key":"2023013110282363800_B4","doi-asserted-by":"crossref","first-page":"D707","DOI":"10.1093\/nar\/gkm988","article-title":"Ensembl 2008","volume":"36","author":"Flicek","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2023013110282363800_B5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/1471-2105-9-312","article-title":"MSDmotif: exploring protein sites and motifs","volume":"9","author":"Golovin","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"2023013110282363800_B6","doi-asserted-by":"crossref","first-page":"D515","DOI":"10.1093\/nar\/gkl774","article-title":"MACiE (Mechanism, Annotation and Classification in Enzymes): novel tools for searching catalytic mechanisms","volume":"35","author":"Holliday","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2023013110282363800_B7","first-page":"389","article-title":"Software for rapid prototyping in the pharmaceutical and biotechnology industries","volume":"11","author":"Kappler","year":"2008","journal-title":"Curr. 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