{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T14:49:57Z","timestamp":1676818197423},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The unprecedented complexity of the transcriptomic data obtained in recent years creates opportunities for new genomic studies aimed at interpolating regulatory code of gene expression and tracing genome evolution. We report here the identification and characterization of a set of 851 intergenic loci that represent transcribed gene fragments (TGFs) ectopically duplicated from 1030 non-transposable element (non-TE) donor genes in the rice genome. We analyzed the genomic context of the TGFs and donor genes. We show that the TGFs have adopted transcriptional orientation and pattern independent of the donor genes. We further show that TGFs have undergone relaxed purifying selection, consistent with their being pseudogenized. We found that the donor genes, which are biased toward certain molecular functions, exhibit an accelerated evolution rate comparing to the genome average. Our results demonstrated a large number of actively TGFs in the rice genome and shed light on the origin, mode of action and function of the TGFs.<\/jats:p>\n               <jats:p>Contact: \u00a0114jn@virginia.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp147","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T00:34:13Z","timestamp":1237250053000},"page":"1215-1218","source":"Crossref","is-referenced-by-count":2,"title":["Transcriptionally active gene fragments derived from potentially fast-evolving donor genes in the rice genome"],"prefix":"10.1093","volume":"25","author":[{"given":"Xiangfeng","family":"Wang","sequence":"first","affiliation":[{"name":"1 Department of Molecular, Cell and Developmental Biology, Yale University, New Haven, CT 06520 and 2Department of Biology, University of Virginia, Charlottesville, VA 22904, USA"}]},{"given":"Zhihui","family":"Yu","sequence":"additional","affiliation":[{"name":"1 Department of Molecular, Cell and Developmental Biology, Yale University, New Haven, CT 06520 and 2Department of Biology, University of Virginia, Charlottesville, VA 22904, USA"}]},{"given":"Xiaozeng","family":"Yang","sequence":"additional","affiliation":[{"name":"1 Department of Molecular, Cell and Developmental Biology, Yale University, New Haven, CT 06520 and 2Department of Biology, University of Virginia, Charlottesville, VA 22904, USA"}]},{"given":"Xing-Wang","family":"Deng","sequence":"additional","affiliation":[{"name":"1 Department of Molecular, Cell and Developmental Biology, Yale University, New Haven, CT 06520 and 2Department of Biology, University of Virginia, Charlottesville, VA 22904, USA"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"1 Department of Molecular, Cell and Developmental Biology, Yale University, New Haven, CT 06520 and 2Department of Biology, University of Virginia, Charlottesville, VA 22904, USA"}]}],"member":"286","published-online":{"date-parts":[[2009,3,16]]},"reference":[{"key":"2023013110283545800_B1","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1126\/science.1103388","article-title":"Global identification of human transcribed sequences with genome tiling arrays","volume":"306","author":"Bertone","year":"2004","journal-title":"Science"},{"key":"2023013110283545800_B2","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1126\/science.1108625","article-title":"Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution","volume":"308","author":"Cheng","year":"2005","journal-title":"Science"},{"key":"2023013110283545800_B3","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1101\/gr.6611807","article-title":"Mapping the C. elegans noncoding transcriptome with a whole-genome tiling microarray","volume":"17","author":"He","year":"2007","journal-title":"Genome Res."},{"key":"2023013110283545800_B4","first-page":"4608","article-title":"Genetic evidence for promoter competition in Saccharomyces cerevisiae","volume":"8","author":"Hirschman","year":"1988","journal-title":"Mol. 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