{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:55:02Z","timestamp":1773665702279,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2748,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: CNVVdb is a web interface for identification of putative copy number variations (CNVs) among 16 vertebrate species using the-same-species self-alignments and cross-species pairwise alignments. By querying genomic coordinates in the target species, all the potential paralogous\/orthologous regions that overlap \u226580\u2013100% (adjustable) of the query sequences with user-specified sequence identity (\u226560%\u223c\u226590%) are returned. Additional information is also given for the genes that are included in the returned regions, including gene description, alternatively spliced transcripts, gene ontology descriptions and other biologically important information. CNVVdb also provides information of pseudogenes and single nucleotide polymorphisms (SNPs) for the CNV-related genomic regions. Moreover, multiple sequence alignments of shared CNVs across species are also provided. With the combination of CNV, SNP, pseudogene and functional information, CNVVdb can be very useful for comparative and functional studies in vertebrates.<\/jats:p>\n               <jats:p>Availability: CNVVdb is freely accessible at http:\/\/CNVVdb.genomics.sinica.edu.tw.<\/jats:p>\n               <jats:p>Contact: \u00a0trees@gate.sinica.edu.tw<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp166","type":"journal-article","created":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T01:54:27Z","timestamp":1238032467000},"page":"1419-1421","source":"Crossref","is-referenced-by-count":8,"title":["CNVVdb: a database of copy number variations across vertebrate genomes"],"prefix":"10.1093","volume":"25","author":[{"given":"Feng-Chi","family":"Chen","sequence":"first","affiliation":[{"name":"1 Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 350 and 2Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan"}]},{"given":"Yen-Zho","family":"Chen","sequence":"additional","affiliation":[{"name":"1 Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 350 and 2Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan"}]},{"given":"Trees-Juen","family":"Chuang","sequence":"additional","affiliation":[{"name":"1 Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 350 and 2Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan"}]}],"member":"286","published-online":{"date-parts":[[2009,3,25]]},"reference":[{"key":"2023013111501768600_B1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/1471-2164-8-391","article-title":"Database of Trypanosoma cruzi repeated genes: 20,000 additional gene variants","volume":"8","author":"Arner","year":"2007","journal-title":"BMC genomics"},{"key":"2023013111501768600_B2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1101\/gr.187101","article-title":"Segmental duplications: organization and impact within the current human genome project assembly","volume":"11","author":"Bailey","year":"2001","journal-title":"Genome Res."},{"key":"2023013111501768600_B3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ng0504-431","article-title":"The genetic association database","volume":"36","author":"Becker","year":"2004","journal-title":"Nat. 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