{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:34:10Z","timestamp":1760708050985,"version":"3.37.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: There is increasing evidence showing that co-expression of genes that cluster along the genome is a common characteristic of eukaryotic transcriptomes. Several algorithms have been used to date in the identification of these kinds of gene organization. Here, we present a web tool called CROC that aims to help in the identification and analysis of genomic gene clusters. This method has been successfully used before in the identification of chromosomal clusters in different eukaryotic species.<\/jats:p><jats:p>Availability: The web server is freely available to non-commercial users at the following address: http:\/\/metagenomics.uv.es\/CROC\/<\/jats:p><jats:p>Contact: \u00a0miguel.pignatelli@uv.es<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp248","type":"journal-article","created":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:25:34Z","timestamp":1240532734000},"page":"1552-1553","source":"Crossref","is-referenced-by-count":24,"title":["CROC: finding chromosomal clusters in eukaryotic genomes"],"prefix":"10.1093","volume":"25","author":[{"given":"Miguel","family":"Pignatelli","sequence":"first","affiliation":[{"name":"1 Instituto Cavanilles of Biodiversity and Evolutionary Biology, University of Valencia, Apdo 22085, 46071 Valencia, Spain and CIBER of Epidemiology and Public Health (CIBERESP), 2Departament de Gen\u00f3tica and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Diagonal 645, 08028 Barcelona and 3Centre de Regulaci\u00f3 Gen\u00f3mica i Grup de Recerca en Inform\u00e1tica Biom\u00e9dica, IMIM-UPF, Parc de Recerca Biom\u00e9dica de Barcelona, Dr. Aiguader 88, 08003 Barcelona, Catalonia, Spain"}]},{"given":"Florenci","family":"Serras","sequence":"additional","affiliation":[{"name":"1 Instituto Cavanilles of Biodiversity and Evolutionary Biology, University of Valencia, Apdo 22085, 46071 Valencia, Spain and CIBER of Epidemiology and Public Health (CIBERESP), 2Departament de Gen\u00f3tica and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Diagonal 645, 08028 Barcelona and 3Centre de Regulaci\u00f3 Gen\u00f3mica i Grup de Recerca en Inform\u00e1tica Biom\u00e9dica, IMIM-UPF, Parc de Recerca Biom\u00e9dica de Barcelona, Dr. Aiguader 88, 08003 Barcelona, Catalonia, Spain"}]},{"given":"Andr\u00e9s","family":"Moya","sequence":"additional","affiliation":[{"name":"1 Instituto Cavanilles of Biodiversity and Evolutionary Biology, University of Valencia, Apdo 22085, 46071 Valencia, Spain and CIBER of Epidemiology and Public Health (CIBERESP), 2Departament de Gen\u00f3tica and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Diagonal 645, 08028 Barcelona and 3Centre de Regulaci\u00f3 Gen\u00f3mica i Grup de Recerca en Inform\u00e1tica Biom\u00e9dica, IMIM-UPF, Parc de Recerca Biom\u00e9dica de Barcelona, Dr. Aiguader 88, 08003 Barcelona, Catalonia, Spain"}]},{"given":"Roderic","family":"Guig\u00f3","sequence":"additional","affiliation":[{"name":"1 Instituto Cavanilles of Biodiversity and Evolutionary Biology, University of Valencia, Apdo 22085, 46071 Valencia, Spain and CIBER of Epidemiology and Public Health (CIBERESP), 2Departament de Gen\u00f3tica and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Diagonal 645, 08028 Barcelona and 3Centre de Regulaci\u00f3 Gen\u00f3mica i Grup de Recerca en Inform\u00e1tica Biom\u00e9dica, IMIM-UPF, Parc de Recerca Biom\u00e9dica de Barcelona, Dr. Aiguader 88, 08003 Barcelona, Catalonia, Spain"}]},{"given":"Montserrat","family":"Corominas","sequence":"additional","affiliation":[{"name":"1 Instituto Cavanilles of Biodiversity and Evolutionary Biology, University of Valencia, Apdo 22085, 46071 Valencia, Spain and CIBER of Epidemiology and Public Health (CIBERESP), 2Departament de Gen\u00f3tica and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Diagonal 645, 08028 Barcelona and 3Centre de Regulaci\u00f3 Gen\u00f3mica i Grup de Recerca en Inform\u00e1tica Biom\u00e9dica, IMIM-UPF, Parc de Recerca Biom\u00e9dica de Barcelona, Dr. Aiguader 88, 08003 Barcelona, Catalonia, Spain"}]}],"member":"286","published-online":{"date-parts":[[2009,4,23]]},"reference":[{"key":"2023013111584720500_B1","doi-asserted-by":"crossref","first-page":"R134","DOI":"10.1186\/gb-2008-9-9-r134","article-title":"Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila","volume":"9","author":"Blanco","year":"2008","journal-title":"Genome Biol"},{"key":"2023013111584720500_B2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. 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