{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:37:23Z","timestamp":1772087843126,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary:The program Fluctuation AnaLysis CalculatOR (FALCOR) is a web tool designed for use with Luria\u2013Delbr\u00fcck fluctuation analysis to calculate the frequency and rate from various mutation assays in bacteria and yeast. Three calculation methods are available through this program: (i) Ma-Sandri-Sarkar Maximum Likelihood Estimator (MSS-MLE) method, (ii) Lea-Coulson method of the median (LC) and (iii) frequency.<\/jats:p>\n               <jats:p>Availability: The FALCOR rate calculator is currently accessible at http:\/\/www.mitochondria.org\/protocols\/FALCOR.html. This program is written as a Java\u2122 Applet, requiring a web browser enabled with Sun MicroSystems' Java Virtual Machine.<\/jats:p>\n               <jats:p>Contact: \u00a0brandon.hall@roswellpark.org<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp253","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T01:28:58Z","timestamp":1239845338000},"page":"1564-1565","source":"Crossref","is-referenced-by-count":363,"title":["Fluctuation AnaLysis CalculatOR: a web tool for the determination of mutation rate using Luria\u2013Delbr\u00fcck fluctuation analysis"],"prefix":"10.1093","volume":"25","author":[{"given":"Brandon M.","family":"Hall","sequence":"first","affiliation":[{"name":"1 Department of Cancer Genetics, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, 2Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY 14214, USA and 3Department of Biological Sciences, Brock University, St. Catharines, Ontario L2S 3A1, Canada"}]},{"given":"Chang-Xing","family":"Ma","sequence":"additional","affiliation":[{"name":"1 Department of Cancer Genetics, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, 2Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY 14214, USA and 3Department of Biological Sciences, Brock University, St. Catharines, Ontario L2S 3A1, Canada"}]},{"given":"Ping","family":"Liang","sequence":"additional","affiliation":[{"name":"1 Department of Cancer Genetics, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, 2Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY 14214, USA and 3Department of Biological Sciences, Brock University, St. Catharines, Ontario L2S 3A1, Canada"}]},{"given":"Keshav K.","family":"Singh","sequence":"additional","affiliation":[{"name":"1 Department of Cancer Genetics, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, 2Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY 14214, USA and 3Department of Biological Sciences, Brock University, St. Catharines, Ontario L2S 3A1, Canada"}]}],"member":"286","published-online":{"date-parts":[[2009,4,15]]},"reference":[{"key":"2023013112003964300_B1","doi-asserted-by":"crossref","first-page":"12404","DOI":"10.1073\/pnas.95.21.12404","article-title":"The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frame shift mutations","volume":"95","author":"Flores-Rojas","year":"1998","journal-title":"Proc. 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