{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:47:37Z","timestamp":1767844057489,"version":"3.49.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Metal-MACiE is a new publicly available web-based database, held in MySQL, which aims to organize the available information on the properties and the roles of metals in the context of the catalytic mechanisms of metalloenzymes. Metal-MACiE, which currently covers 75% of metal-dependent enzyme commission (EC) sub-sub-classes and is continuously growing, exploits the existing MACiE database for the annotation of the reaction mechanisms. The two databases constitute complementary sources of information for enzymology, biochemistry and molecular pharmacology studies.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.ebi.ac.uk\/thornton-srv\/databases\/Metal_MACiE\/home.html<\/jats:p>\n               <jats:p>Contact: \u00a0andreini@cerm.unifi.it<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp256","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T01:28:58Z","timestamp":1239845338000},"page":"2088-2089","source":"Crossref","is-referenced-by-count":70,"title":["Metal-MACiE: a database of metals involved in biological catalysis"],"prefix":"10.1093","volume":"25","author":[{"given":"Claudia","family":"Andreini","sequence":"first","affiliation":[{"name":"1 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 2Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy and 3EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"},{"name":"1 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 2Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy and 3EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]},{"given":"Ivano","family":"Bertini","sequence":"additional","affiliation":[{"name":"1 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 2Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy and 3EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"},{"name":"1 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 2Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy and 3EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]},{"given":"Gabriele","family":"Cavallaro","sequence":"additional","affiliation":[{"name":"1 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 2Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy and 3EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"},{"name":"1 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 2Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy and 3EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]},{"given":"Gemma L.","family":"Holliday","sequence":"additional","affiliation":[{"name":"1 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 2Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy and 3EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]},{"given":"Janet M.","family":"Thornton","sequence":"additional","affiliation":[{"name":"1 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 2Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy and 3EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]}],"member":"286","published-online":{"date-parts":[[2009,4,15]]},"reference":[{"key":"2023013112094575900_B1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00775-008-0404-5","article-title":"Metal ions in biological catalysis: from enzyme databases to general principles","volume":"13","author":"Andreini","year":"2008","journal-title":"J. Biol. Inorg. 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