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Specifically, CycSim supports the design of knockout experiments: simulation of growth phenotypes of single or multiple gene deletions mutants on specified media, comparison of these predictions with experimental phenotypes and direct visualization of both on metabolic maps. The web interface is designed for simplicity, putting constraint-based modelling techniques within easier reach of biologists. CycSim also functions as an online repository of genome-scale metabolic models.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.genoscope.cns.fr\/cycsim<\/jats:p>\n               <jats:p>Contact: \u00a0cycsim@genoscope.cns.fr<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp268","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T00:44:24Z","timestamp":1241657064000},"page":"1987-1988","source":"Crossref","is-referenced-by-count":23,"title":["CycSim\u2014an online tool for exploring and experimenting with genome-scale metabolic models"],"prefix":"10.1093","volume":"25","author":[{"given":"F.","family":"Le F\u00e8vre","sequence":"first","affiliation":[{"name":"1 CEA, DSV, IG, Genoscope, UMR 8030, Evry, F-91057 and 2 IBISC, FRE 3190 CNRS, Universit\u00e9 d'Evry, Evry, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Smidtas","sequence":"additional","affiliation":[{"name":"1 CEA, DSV, IG, Genoscope, UMR 8030, Evry, F-91057 and 2 IBISC, FRE 3190 CNRS, Universit\u00e9 d'Evry, Evry, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Combe","sequence":"additional","affiliation":[{"name":"1 CEA, DSV, IG, Genoscope, UMR 8030, Evry, F-91057 and 2 IBISC, FRE 3190 CNRS, Universit\u00e9 d'Evry, Evry, France"},{"name":"1 CEA, DSV, IG, Genoscope, UMR 8030, Evry, F-91057 and 2 IBISC, FRE 3190 CNRS, Universit\u00e9 d'Evry, Evry, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Durot","sequence":"additional","affiliation":[{"name":"1 CEA, DSV, IG, Genoscope, UMR 8030, Evry, F-91057 and 2 IBISC, FRE 3190 CNRS, Universit\u00e9 d'Evry, Evry, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"d'Alch\u00e9-Buc","sequence":"additional","affiliation":[{"name":"1 CEA, DSV, IG, Genoscope, UMR 8030, Evry, F-91057 and 2 IBISC, FRE 3190 CNRS, Universit\u00e9 d'Evry, Evry, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Schachter","sequence":"additional","affiliation":[{"name":"1 CEA, DSV, IG, Genoscope, UMR 8030, Evry, F-91057 and 2 IBISC, FRE 3190 CNRS, Universit\u00e9 d'Evry, Evry, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,5,6]]},"reference":[{"key":"2023013112094826500_B1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nprot.2007.99","article-title":"Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox","volume":"2","author":"Becker","year":"2007","journal-title":"Nat. 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