{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:20:24Z","timestamp":1761862824882},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: InterMap3D predicts co-evolving protein residues and plots them on the 3D protein structure. Starting with a single protein sequence, InterMap3D automatically finds a set of homologous sequences, generates an alignment and fetches the most similar 3D structure from the Protein Data Bank (PDB). It can also accept a user-generated alignment. Based on the alignment, co-evolving residues are then predicted using three different methods: Row and Column Weighing of Mutual Information, Mutual Information\/Entropy and Dependency. Finally, InterMap3D generates high-quality images of the protein with the predicted co-evolving residues highlighted.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.cbs.dtu.dk\/services\/InterMap3D\/<\/jats:p>\n               <jats:p>Contact: \u00a0gorm@cbs.dtu.dk<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp335","type":"journal-article","created":{"date-parts":[[2009,6,16]],"date-time":"2009-06-16T00:26:03Z","timestamp":1245111963000},"page":"1963-1965","source":"Crossref","is-referenced-by-count":20,"title":["InterMap3D: predicting and visualizing co-evolving protein residues"],"prefix":"10.1093","volume":"25","author":[{"given":"Rodrigo","family":"Gouveia-Oliveira","sequence":"first","affiliation":[{"name":"Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark"}]},{"given":"Francisco S.","family":"Roque","sequence":"additional","affiliation":[{"name":"Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark"}]},{"given":"Rasmus","family":"Wernersson","sequence":"additional","affiliation":[{"name":"Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark"}]},{"given":"Thomas","family":"Sicheritz-Ponten","sequence":"additional","affiliation":[{"name":"Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark"}]},{"given":"Peter W.","family":"Sackett","sequence":"additional","affiliation":[{"name":"Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark"}]},{"given":"Anne","family":"M\u00f8lgaard","sequence":"additional","affiliation":[{"name":"Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark"}]},{"given":"Anders G.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark"}]}],"member":"286","published-online":{"date-parts":[[2009,6,15]]},"reference":[{"key":"2023013112050624900_B1","doi-asserted-by":"crossref","first-page":"D115","DOI":"10.1093\/nar\/gkh131","article-title":"UniProt: the Universal Protein knowledgebase","volume":"32","author":"Apweiler","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"2023013112050624900_B2","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4471-3675-0","volume-title":"An Introduction to Statistical Modelling of Extreme Values","author":"Coles","year":"2001"},{"key":"2023013112050624900_B3","volume-title":"The PyMOL Graphics System.","author":"Delano","year":"2002"},{"key":"2023013112050624900_B4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/1471-2148-7-242","article-title":"Detecting groups of coevolving positions in a molecule: a clustering approach","volume":"7","author":"Dutheil","year":"2007","journal-title":"BMC Evol. 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