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An editor allows the intuitive and hierarchically structured specification of cellular behavior. The models are then automatically compiled into highly efficient source code and dynamically linked to an interactive graphical simulation environment. The system allows the quantitative analysis of the morphological and functional tissue properties emerging from the cell behavioral model. We demonstrate the relevance of the approach using a recently published model of epidermal homeostasis as well as a series of cell-cycle models.<\/jats:p>\n               <jats:p>Availability: The complete software is available in binary executables for MS-Windows and Linux at tiga.uni-hd.de<\/jats:p>\n               <jats:p>Contact: \u00a0niels.grabe@bioquant.uni-heidelberg.de<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp361","type":"journal-article","created":{"date-parts":[[2009,6,18]],"date-time":"2009-06-18T01:45:34Z","timestamp":1245289534000},"page":"2057-2063","source":"Crossref","is-referenced-by-count":25,"title":["Modeling multi-cellular behavior in epidermal tissue homeostasis via finite state machines in multi-agent systems"],"prefix":"10.1093","volume":"25","author":[{"given":"Thomas","family":"S\u00fctterlin","sequence":"first","affiliation":[{"name":"1 Medical Informatics Department, Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Im Neuenheimer Feld 305 and Hamamatsu Tissue Imaging and Analysis Center (TIGA), BIOQUANT, University Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg and 2 Department of Informatics, Heilbronn University, Max-Planck-Str. 39, 74081 Heilbronn, Germany"}]},{"given":"Simone","family":"Huber","sequence":"additional","affiliation":[{"name":"1 Medical Informatics Department, Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Im Neuenheimer Feld 305 and Hamamatsu Tissue Imaging and Analysis Center (TIGA), BIOQUANT, University Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg and 2 Department of Informatics, Heilbronn University, Max-Planck-Str. 39, 74081 Heilbronn, Germany"}]},{"given":"Hartmut","family":"Dickhaus","sequence":"additional","affiliation":[{"name":"1 Medical Informatics Department, Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Im Neuenheimer Feld 305 and Hamamatsu Tissue Imaging and Analysis Center (TIGA), BIOQUANT, University Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg and 2 Department of Informatics, Heilbronn University, Max-Planck-Str. 39, 74081 Heilbronn, Germany"}]},{"given":"Niels","family":"Grabe","sequence":"additional","affiliation":[{"name":"1 Medical Informatics Department, Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Im Neuenheimer Feld 305 and Hamamatsu Tissue Imaging and Analysis Center (TIGA), BIOQUANT, University Heidelberg, Im Neuenheimer Feld 267, 69120 Heidelberg and 2 Department of Informatics, Heilbronn University, Max-Planck-Str. 39, 74081 Heilbronn, Germany"}]}],"member":"286","published-online":{"date-parts":[[2009,6,17]]},"reference":[{"key":"2023013112093427200_B1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0022-5193(03)00244-3","article-title":"A cellular automaton model for tumour growth in inhomogeneous environment","volume":"225","author":"Alarcon","year":"2003","journal-title":"J. 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