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SSC is the first tool to allow a readable high-level description with spatially heterogeneous simulation algorithms and complex geometries; this permits large systems to be expressed concisely. Meanwhile, direct native-code compilation allows SSC to generate very fast simulations.<\/jats:p>\n               <jats:p>Availability: SSC currently runs on Linux and Mac OS X, and is freely available at http:\/\/web.mit.edu\/irc\/ssc\/.<\/jats:p>\n               <jats:p>Contact: \u00a0mieszko@csail.mit.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp387","type":"journal-article","created":{"date-parts":[[2009,7,4]],"date-time":"2009-07-04T00:24:32Z","timestamp":1246667072000},"page":"2289-2291","source":"Crossref","is-referenced-by-count":47,"title":["Efficient stochastic simulation of reaction\u2013diffusion processes via direct compilation"],"prefix":"10.1093","volume":"25","author":[{"given":"Mieszko","family":"Lis","sequence":"first","affiliation":[{"name":"1 Computer Science and Artificial Intelligence Laboratory and the Departments of2 Chemistry, 3 Chemical Engineering and 4 Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim N.","family":"Artyomov","sequence":"additional","affiliation":[{"name":"1 Computer Science and Artificial Intelligence Laboratory and the Departments of2 Chemistry, 3 Chemical Engineering and 4 Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivas","family":"Devadas","sequence":"additional","affiliation":[{"name":"1 Computer Science and Artificial Intelligence Laboratory and the Departments of2 Chemistry, 3 Chemical Engineering and 4 Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arup K.","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"1 Computer Science and Artificial Intelligence Laboratory and the Departments of2 Chemistry, 3 Chemical Engineering and 4 Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"},{"name":"1 Computer Science and Artificial Intelligence Laboratory and the Departments of2 Chemistry, 3 Chemical Engineering and 4 Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"},{"name":"1 Computer Science and Artificial Intelligence Laboratory and the Departments of2 Chemistry, 3 Chemical Engineering and 4 Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,7,3]]},"reference":[{"key":"2023013112105018100_B1","doi-asserted-by":"crossref","first-page":"18958","DOI":"10.1073\/pnas.0706110104","article-title":"Purely stochastic binary decisions in cell signaling models without underlying deterministic bistabilities","volume":"104","author":"Artyomov","year":"2007","journal-title":"Proc. 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