{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:43:22Z","timestamp":1761101002508},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Minor histocompatibility antigens (mHags) are a diverse collection of MHC-bound peptides that have immunological implications in the context of allogeneic transplantation because of their differential presence in donor and host, and thus play a critical role in the induction of the detrimental graft-versus-host disease (GvHD) or in the development of the beneficial graft-versus-leukemia (GvL) effect. Therefore, the search for mHags has implications not only for preventing GvHD, but also for therapeutic applications involving leukemia-specific T cells. We have created a web-based system, named PeptideCheck, which aims to augment the experimental discovery of mHags using bioinformatic means. Analyzing peptide elution data to search for mHags and predicting mHags from polymorphism and protein databases are the core features.<\/jats:p>\n               <jats:p>Results: Comparison with known mHag data reveals that some but not all of the previously known mHags can be reproduced. By applying a system of filtering and ranking, we were able to produce an ordered list of potential mHag candidates in which HA-1, HA-3 and HA-8 occur in the best 0.25%. By combining single nucleotide polymorphism, protein, tissue expression and genotypic frequency data, together with antigen presentation prediction algorithms, we propose a list of the best peptide candidates which could potentially induce the GvL effect without causing GvFD.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.peptidecheck.org<\/jats:p>\n               <jats:p>Contact: \u00a0blasczyk.rainer@mh-hannover.de<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp404","type":"journal-article","created":{"date-parts":[[2009,7,2]],"date-time":"2009-07-02T00:40:46Z","timestamp":1246495246000},"page":"2411-2417","source":"Crossref","is-referenced-by-count":11,"title":["High-throughput minor histocompatibility antigen prediction"],"prefix":"10.1093","volume":"25","author":[{"given":"David S.","family":"DeLuca","sequence":"first","affiliation":[{"name":"1 Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany and 2Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"},{"name":"1 Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany and 2Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"}]},{"given":"Britta","family":"Eiz-Vesper","sequence":"additional","affiliation":[{"name":"1 Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany and 2Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"}]},{"given":"Nektarios","family":"Ladas","sequence":"additional","affiliation":[{"name":"1 Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany and 2Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"}]},{"given":"Barbara Anna-Maria","family":"Khattab","sequence":"additional","affiliation":[{"name":"1 Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany and 2Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"}]},{"given":"Rainer","family":"Blasczyk","sequence":"additional","affiliation":[{"name":"1 Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany and 2Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"}]}],"member":"286","published-online":{"date-parts":[[2009,7,1]]},"reference":[{"key":"2023013112122039600_B1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/nar\/gkg095","article-title":"The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003","volume":"31","author":"Boeckmann","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"2023013112122039600_B2","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1182\/blood-2005-08-3501","article-title":"The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL","volume":"107","author":"Brickner","year":"2006","journal-title":"Blood"},{"key":"2023013112122039600_B3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/bioinformatics\/14.2.121","article-title":"Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network","volume":"14","author":"Brusic","year":"1998","journal-title":"Bioinformatics"},{"key":"2023013112122039600_B4","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1034\/j.1399-0039.2003.00112.x","article-title":"Sensitive quantitative predictions of peptide-MHC binding by a \u2018Query by Committee\u2019 artificial neural network approach","volume":"62","author":"Buus","year":"2003","journal-title":"Tissue Antigens"},{"key":"2023013112122039600_B5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1399-0039.2007.00914.x","article-title":"The immunoinformatics of cancer immunotherapy","volume":"70","author":"DeLuca","year":"2007","journal-title":"Tissue Antigens"},{"key":"2023013112122039600_B6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00251-006-0176-4","article-title":"A modular concept of HLA for comprehensive peptide binding prediction","volume":"59","author":"DeLuca","year":"2007","journal-title":"Immunogenetics"},{"key":"2023013112122039600_B7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/bioinformatics\/btm616","article-title":"Precise score for the prediction of peptides cleaved by the proteasome","volume":"24","author":"Ginodi","year":"2008","journal-title":"Bioinformatics"},{"key":"2023013112122039600_B8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1056\/NEJM199602013340501","article-title":"Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation","volume":"334","author":"Goulmy","year":"1996","journal-title":"N. 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