{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:30:51Z","timestamp":1758709851619},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We identified 5 975 567 mono- and 6 995 122 di-nucleosome positions of the fungus Aspergillus fumigatus, which was detected at high resolution based on the DNA sequence data obtained from both mono- and di-nucleosomal DNA fragments. We show that the distribution of lengths of the mono-nucleosomal DNA fragments has two peaks at 135 and 150 nt, whereas the distribution of di-nucleosomal DNA fragment lengths has a single peak at 285 nt. Although the gene bodies of the active and inactive genes and the inactive gene promoters had the two peaks of the mono-nucleosomal DNA fragment lengths, the active gene promoter lost the longer peak at 150 nt. Our findings strongly suggest that the nucleosomes protecting longer DNA fragments against MNase at the promoters, thereby inhibiting high gene expression.<\/jats:p>\n               <jats:p>Contact: \u00a0hnishida@iu.a.u-tokyo.ac.jp<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp413","type":"journal-article","created":{"date-parts":[[2009,7,2]],"date-time":"2009-07-02T00:40:46Z","timestamp":1246495246000},"page":"2295-2297","source":"Crossref","is-referenced-by-count":12,"title":["Genome-wide maps of mono- and di-nucleosomes of <i>Aspergillus fumigatus<\/i>"],"prefix":"10.1093","volume":"25","author":[{"given":"Hiromi","family":"Nishida","sequence":"first","affiliation":[{"name":"1 Agricultural Bioinformatics Research Unit, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, 2Antibiotics Laboratory, Advanced Science Institute, RIKEN, Wako, Saitama 351-0198 and 3Research Center for Advance Science and Technology, University of Tokyo, Tokyo 153-8904, Japan"}]},{"given":"Takayuki","family":"Motoyama","sequence":"additional","affiliation":[{"name":"1 Agricultural Bioinformatics Research Unit, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, 2Antibiotics Laboratory, Advanced Science Institute, RIKEN, Wako, Saitama 351-0198 and 3Research Center for Advance Science and Technology, University of Tokyo, Tokyo 153-8904, Japan"}]},{"given":"Shogo","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"1 Agricultural Bioinformatics Research Unit, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, 2Antibiotics Laboratory, Advanced Science Institute, RIKEN, Wako, Saitama 351-0198 and 3Research Center for Advance Science and Technology, University of Tokyo, Tokyo 153-8904, Japan"}]},{"given":"Hiroyuki","family":"Aburatani","sequence":"additional","affiliation":[{"name":"1 Agricultural Bioinformatics Research Unit, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, 2Antibiotics Laboratory, Advanced Science Institute, RIKEN, Wako, Saitama 351-0198 and 3Research Center for Advance Science and Technology, University of Tokyo, Tokyo 153-8904, Japan"}]},{"given":"Hiroyuki","family":"Osada","sequence":"additional","affiliation":[{"name":"1 Agricultural Bioinformatics Research Unit, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, 2Antibiotics Laboratory, Advanced Science Institute, RIKEN, Wako, Saitama 351-0198 and 3Research Center for Advance Science and Technology, University of Tokyo, Tokyo 153-8904, Japan"}]}],"member":"286","published-online":{"date-parts":[[2009,7,1]]},"reference":[{"key":"2023013112120949600_B1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1101\/gr.5636607","article-title":"Independent and complementary methods for large-scale structural analysis of mammalian chromatin","volume":"17","author":"Dennis","year":"2007","journal-title":"Genome Res."},{"key":"2023013112120949600_B2","doi-asserted-by":"crossref","first-page":"e1000138","DOI":"10.1371\/journal.pgen.1000138","article-title":"The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome","volume":"4","author":"Fu","year":"2008","journal-title":"PLoS Genet"},{"key":"2023013112120949600_B3","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1093\/nar\/25.19.3955","article-title":"A rapid method for chromatin structure analysis in the filamentous fungus Aspergillus nidulans","volume":"25","author":"Gonzalez","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023013112120949600_B4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1101\/gr.087619.108","article-title":"Genome-wide profiling of salt fractions maps physical properties of chromatin","volume":"19","author":"Henikoff","year":"2009","journal-title":"Genome Res."},{"key":"2023013112120949600_B5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.bi.51.070182.000513","article-title":"Chromatin","volume":"51","author":"Igo-Kemenes","year":"1982","journal-title":"Annu. 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