{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:28:43Z","timestamp":1769239723657,"version":"3.49.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Most of the structures and functions of proteome globular domains are yet unknown. We can use high-resolution structures from different modular domains in combination with automatic protein design algorithms to predict genome-wide potential interactions of a protein. ADAN database and related web tools are online resources for the predictive analysis of ligand\u2013domain complexes. ADAN database is a collection of different modular protein domains (SH2, SH3, PDZ, WW, etc.). It contains 3505 entries with extensive structural and functional information available, manually integrated, curated and annotated with cross-references to other databases, biochemical and thermodynamical data, simplified coordinate files, sequence files and alignments. Prediadan, a subset of ADAN database, offers position-specific scoring matrices for protein\u2013protein interactions, calculated by FoldX, and predictions of optimum ligands and putative binding partners. Users can also scan a query sequence against selected matrices, or improve a ligand\u2013domain interaction.<\/jats:p>\n               <jats:p>Availability: ADAN is accessible at http:\/\/adan-embl.ibmc.umh.es\/ or http:\/\/adan.crg.es\/.<\/jats:p>\n               <jats:p>Contact: \u00a0gregorio@umh.es<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp424","type":"journal-article","created":{"date-parts":[[2009,7,15]],"date-time":"2009-07-15T02:04:52Z","timestamp":1247623492000},"page":"2418-2424","source":"Crossref","is-referenced-by-count":33,"title":["ADAN: a database for prediction of protein\u2013protein interaction of modular domains mediated by linear motifs"],"prefix":"10.1093","volume":"25","author":[{"given":"J. A.","family":"Encinar","sequence":"first","affiliation":[{"name":"1 Instituto de Biolog\u03b9a Molecular y Celular, Edificio Torregaitan, Universidad Miguel Hernandez, 03202 Elche (Alicante), Spain, 2Fundaci\u00f3n Instituto Leloir and IIBBA-CONICET, Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina, 3EMBL\/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, 08003 Barcelona, Spain and 4Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"G.","family":"Fernandez-Ballester","sequence":"additional","affiliation":[{"name":"1 Instituto de Biolog\u03b9a Molecular y Celular, Edificio Torregaitan, Universidad Miguel Hernandez, 03202 Elche (Alicante), Spain, 2Fundaci\u00f3n Instituto Leloir and IIBBA-CONICET, Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina, 3EMBL\/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, 08003 Barcelona, Spain and 4Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"I. E.","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"1 Instituto de Biolog\u03b9a Molecular y Celular, Edificio Torregaitan, Universidad Miguel Hernandez, 03202 Elche (Alicante), Spain, 2Fundaci\u00f3n Instituto Leloir and IIBBA-CONICET, Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina, 3EMBL\/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, 08003 Barcelona, Spain and 4Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"E.","family":"Hurtado-Gomez","sequence":"additional","affiliation":[{"name":"1 Instituto de Biolog\u03b9a Molecular y Celular, Edificio Torregaitan, Universidad Miguel Hernandez, 03202 Elche (Alicante), Spain, 2Fundaci\u00f3n Instituto Leloir and IIBBA-CONICET, Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina, 3EMBL\/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, 08003 Barcelona, Spain and 4Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA"},{"name":"1 Instituto de Biolog\u03b9a Molecular y Celular, Edificio Torregaitan, Universidad Miguel Hernandez, 03202 Elche (Alicante), Spain, 2Fundaci\u00f3n Instituto Leloir and IIBBA-CONICET, Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina, 3EMBL\/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, 08003 Barcelona, Spain and 4Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"F.","family":"Stricher","sequence":"additional","affiliation":[{"name":"1 Instituto de Biolog\u03b9a Molecular y Celular, Edificio Torregaitan, Universidad Miguel Hernandez, 03202 Elche (Alicante), Spain, 2Fundaci\u00f3n Instituto Leloir and IIBBA-CONICET, Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina, 3EMBL\/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, 08003 Barcelona, Spain and 4Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"P.","family":"Beltrao","sequence":"additional","affiliation":[{"name":"1 Instituto de Biolog\u03b9a Molecular y Celular, Edificio Torregaitan, Universidad Miguel Hernandez, 03202 Elche (Alicante), Spain, 2Fundaci\u00f3n Instituto Leloir and IIBBA-CONICET, Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina, 3EMBL\/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, 08003 Barcelona, Spain and 4Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA"}]},{"given":"L.","family":"Serrano","sequence":"additional","affiliation":[{"name":"1 Instituto de Biolog\u03b9a Molecular y Celular, Edificio Torregaitan, Universidad Miguel Hernandez, 03202 Elche (Alicante), Spain, 2Fundaci\u00f3n Instituto Leloir and IIBBA-CONICET, Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina, 3EMBL\/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, 08003 Barcelona, Spain and 4Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA"}]}],"member":"286","published-online":{"date-parts":[[2009,7,14]]},"reference":[{"key":"2023013112123271900_B1","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1073\/pnas.092147999","article-title":"Interrogating protein interaction networks through structural biology","volume":"99","author":"Aloy","year":"2002","journal-title":"Proc. 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