{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:31:36Z","timestamp":1770323496919,"version":"3.49.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":2635,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: DiProGB is an easy to use new genome browser that encodes the primary nucleotide sequence by thermodynamical and geometrical dinucleotide properties. The nucleotide sequence is thus converted into a sequence graph. This visualization, supported by different graph manipulation options, facilitates genome analyses, because the human brain can process visual information better than textual information. Also, DiProGB can identify genomic regions where certain physical properties are more conserved than the nucleotide sequence itself. Most of the DiProGB tools can be applied to both, the primary nucleotide sequence and the sequence graph. They include motif and repeat searches as well as statistical analyses. DiProGB adds a new dimension to the common genome analysis approaches by taking into account the physical properties of DNA and RNA.<\/jats:p>\n               <jats:p>Availability and Implementation: Source code and binaries are freely available for download at http:\/\/diprogb.fli-leibniz.de, implemented in C++ and supported on MS Windows and Linux (using e.g. WineHQ).<\/jats:p>\n               <jats:p>Contact: \u00a0maikfr@fli-leibniz.de; thomas.wilhelm@bbsrc.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp436","type":"journal-article","created":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T00:49:46Z","timestamp":1247705386000},"page":"2603-2604","source":"Crossref","is-referenced-by-count":22,"title":["DiProGB: the dinucleotide properties genome browser"],"prefix":"10.1093","volume":"25","author":[{"given":"Maik","family":"Friedel","sequence":"first","affiliation":[{"name":"1 Biocomputing Group, Leibniz Institute for Age Research \u2013 Fritz Lipmann Institute, Jena Centre for Bioinformatics, Beutenbergstr. 11, 2Systems Biology\/Bioinformatics Group, Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans Kn\u00f6ll Institute, Jena Centre for Bioinformatics, Beutenbergstr. 11a, 07745 Jena, Germany and 3Theoretical Systems Biology, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK"}]},{"given":"Swetlana","family":"Nikolajewa","sequence":"additional","affiliation":[{"name":"1 Biocomputing Group, Leibniz Institute for Age Research \u2013 Fritz Lipmann Institute, Jena Centre for Bioinformatics, Beutenbergstr. 11, 2Systems Biology\/Bioinformatics Group, Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans Kn\u00f6ll Institute, Jena Centre for Bioinformatics, Beutenbergstr. 11a, 07745 Jena, Germany and 3Theoretical Systems Biology, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK"}]},{"given":"J\u00fcrgen","family":"S\u00fchnel","sequence":"additional","affiliation":[{"name":"1 Biocomputing Group, Leibniz Institute for Age Research \u2013 Fritz Lipmann Institute, Jena Centre for Bioinformatics, Beutenbergstr. 11, 2Systems Biology\/Bioinformatics Group, Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans Kn\u00f6ll Institute, Jena Centre for Bioinformatics, Beutenbergstr. 11a, 07745 Jena, Germany and 3Theoretical Systems Biology, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK"}]},{"given":"Thomas","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"1 Biocomputing Group, Leibniz Institute for Age Research \u2013 Fritz Lipmann Institute, Jena Centre for Bioinformatics, Beutenbergstr. 11, 2Systems Biology\/Bioinformatics Group, Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans Kn\u00f6ll Institute, Jena Centre for Bioinformatics, Beutenbergstr. 11a, 07745 Jena, Germany and 3Theoretical Systems Biology, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK"}]}],"member":"286","published-online":{"date-parts":[[2009,7,15]]},"reference":[{"key":"2023013112124158800_B1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1570-8667(03)00065-0","article-title":"Replacing suffix trees with enhanced suffix arrays","volume":"2","author":"Abouelhoda","year":"2004","journal-title":"J. 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