{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T23:40:34Z","timestamp":1769298034681,"version":"3.49.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: We present a tool that assesses the enrichment of significant associations from genome-wide association studies (GWAS) in a pathway context. The SNP ratio test (SRT) compares the proportion of significant to all SNPs within genes that are part of a pathway and computes an empirical P-value based on comparisons to ratios in datasets where the assignment of case\/control status has been randomized. We applied the SRT to a Parkinson's disease GWAS dataset, using the KEGG database, revealing significance for Parkinson's disease and related pathways.<\/jats:p>\n               <jats:p>Availability: \u00a0https:\/\/sourceforge.net\/projects\/snpratiotest\/<\/jats:p>\n               <jats:p>Contact: \u00a0codushlaine@gmail.com; colm.odushlaine@tcd.ie<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp448","type":"journal-article","created":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T00:58:23Z","timestamp":1248137903000},"page":"2762-2763","source":"Crossref","is-referenced-by-count":114,"title":["The SNP ratio test: pathway analysis of genome-wide association datasets"],"prefix":"10.1093","volume":"25","author":[{"given":"Colm","family":"O'Dushlaine","sequence":"first","affiliation":[{"name":"Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Kenny","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Heron","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Segurado","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gill","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek W.","family":"Morris","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiden","family":"Corvin","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,7,20]]},"reference":[{"key":"2023013112132628200_B1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00439-008-0600-y","article-title":"Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission","volume":"125","author":"Askland","year":"2009","journal-title":"Hum. 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