{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T22:40:07Z","timestamp":1675204807725},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Currently, there are a number of databases which store microRNA (miRNA) information, and tools available which provide miRNA target prediction. In this article, we describe a novel web-based tool that integrate the miRNA-targeted mRNA data, protein\u2013protein interactions (PPI) records, tissues, biochemical pathways, human disease and gene function information to establish a disease-related miRNA target pathway database. This database is unique in the sense that it links miRNA target genes with their PPI partners according to being tissue- and diseases-specific or both. The same approach is also applied to siRNA data. This database provides two types of searches: (i) tissue- and (ii) disease-specific miRNA (or siRNA) targeting pathways. The search allows one to identify tissue- or disease-specific miRNA (or siRNA) target gene's PPI partners two levels beyond.<\/jats:p>\n               <jats:p>Availability: The release version 1.0 is a freely accessible database available at http:\/\/ncrnappi.cs.nthu.edu.tw and http:\/\/ncRNAppi.bioinfo.asia.edu.tw\/<\/jats:p>\n               <jats:p>Contact: \u00a0ppiddi@gmail.com; o2snow@gmail.com<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp574","type":"journal-article","created":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T03:44:47Z","timestamp":1254887087000},"page":"3199-3201","source":"Crossref","is-referenced-by-count":2,"title":["ncRNAppi\u2014a tool for identifying disease-related miRNA and siRNA targeting pathways"],"prefix":"10.1093","volume":"25","author":[{"given":"Ka-Lok","family":"Ng","sequence":"first","affiliation":[{"name":"1 Department of Bioinformatics, Asia University, 500 Lioufeng Road, Wufeng Shiang, Taichung, Taiwan 41354, 2 Department of Computer Science, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, Taiwan 30013 and 3 School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan 40201"}]},{"given":"Hsueh-Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"1 Department of Bioinformatics, Asia University, 500 Lioufeng Road, Wufeng Shiang, Taichung, Taiwan 41354, 2 Department of Computer Science, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, Taiwan 30013 and 3 School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan 40201"}]},{"given":"Shan-Chih","family":"Lee","sequence":"additional","affiliation":[{"name":"1 Department of Bioinformatics, Asia University, 500 Lioufeng Road, Wufeng Shiang, Taichung, Taiwan 41354, 2 Department of Computer Science, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, Taiwan 30013 and 3 School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan 40201"}]}],"member":"286","published-online":{"date-parts":[[2009,10,6]]},"reference":[{"key":"2023013112185324000_B1","doi-asserted-by":"crossref","first-page":"D418","DOI":"10.1093\/nar\/gki051","article-title":"The biomolecular interaction network database and related tools 2005 update","volume":"33","author":"Alfarano","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2023013112185324000_B2","doi-asserted-by":"crossref","first-page":"D793","DOI":"10.1093\/nar\/gkn665","article-title":"McKusick's Online Mendelian Inheritance in Man (OMIM)","volume":"37","author":"Amberger","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"2023013112185324000_B3","doi-asserted-by":"crossref","first-page":"D637","DOI":"10.1093\/nar\/gkm1001","article-title":"The BioGRID interaction database: 2008 update","volume":"36","author":"Breitkreutz","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2023013112185324000_B4","volume-title":"Identification of novel tumor-associated gene (TAG) by bioinformatics analysis.","author":"Chan","year":"2006"},{"key":"2023013112185324000_B5","doi-asserted-by":"crossref","first-page":"D572","DOI":"10.1093\/nar\/gkl950","article-title":"MINT: the molecular INTeraction database","volume":"35","author":"Chatraryamontri","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2023013112185324000_B6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs - microRNAs with a role in cancer","volume":"6","author":"Esquela-Kerscher","year":"2006","journal-title":"Nat. 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