{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:30:33Z","timestamp":1753885833216},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Exon arrays allow the quantitative study of alternative splicing (AS) on a genome-wide scale. A variety of splicing prediction methods has been proposed for Affymetrix exon arrays mainly focusing on geometric correlation measures or analysis of variance. In this article, we introduce an information theoretic concept that is based on modification of the well-known entropy function.<\/jats:p>\n               <jats:p>Results: We have developed an AS robust prediction method based on entropy (ARH). We can show that this measure copes with bias inherent in the analysis of AS such as the dependency of prediction performance on the number of exons or variable exon expression. In order to judge the performance of ARH, we have compared it with eight existing splicing prediction methods using experimental benchmark data and demonstrate that ARH is a well-performing new method for the prediction of splice variants.<\/jats:p>\n               <jats:p>Availability and Implementation: ARH is implemented in R and provided in the Supplementary Material.<\/jats:p>\n               <jats:p>Contact: \u00a0rasche@molgen.mpg.de<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp626","type":"journal-article","created":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T02:18:51Z","timestamp":1257387531000},"page":"84-90","source":"Crossref","is-referenced-by-count":16,"title":["ARH: predicting splice variants from genome-wide data with modified entropy"],"prefix":"10.1093","volume":"26","author":[{"given":"Axel","family":"Rasche","sequence":"first","affiliation":[{"name":"Department of Vertebrate Genomics, Max-Planck-Institute for Molecular Genetics, Ihnestr. 63-73, D-14195 Berlin, Germany"}]},{"given":"Ralf","family":"Herwig","sequence":"additional","affiliation":[{"name":"Department of Vertebrate Genomics, Max-Planck-Institute for Molecular Genetics, Ihnestr. 63-73, D-14195 Berlin, Germany"}]}],"member":"286","published-online":{"date-parts":[[2009,11,4]]},"reference":[{"key":"2023012507533557700_B1","doi-asserted-by":"crossref","first-page":"e913","DOI":"10.1371\/journal.pone.0000913","article-title":"Experimental comparison and evaluation of the Affymetrix exon and u133plus2 genechip arrays","volume":"2","author":"Abdueva","year":"2007","journal-title":"PLoS ONE"},{"key":"2023012507533557700_B2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1186\/1471-2164-9-571","article-title":"Dissecting an alternative splicing analysis workflow for genechip exon 1.0 st Affymetrix arrays","volume":"9","author":"Beffa","year":"2008","journal-title":"BMC Genomics"},{"key":"2023012507533557700_B3","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1074\/jbc.R700033200","article-title":"Genome-wide analysis of alternative pre-mRNA splicing","volume":"283","author":"Ben-Dov","year":"2008","journal-title":"J. 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