{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:07:45Z","timestamp":1768028865616,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by inhibiting target mRNA genes. Their tissue- and disease-specific expression patterns have immense therapeutic and diagnostic potential. To understand these patterns, a reliable compilation of miRNA and mRNA expression data is required to compare multiple tissue types. Moreover, with the appropriate statistical tools, such a resource could be interrogated to discover functionally related miRNA\u2013mRNA pairs.<\/jats:p>\n               <jats:p>Results:We have developed mimiRNA, an online resource that integrates expression data from 1483 samples and permits visualization of the expression of 635 human miRNAs across 188 different tissues or cell types. mimiRNA incorporates a novel sample classification algorithm, ExParser, that groups identical miRNA or mRNA experiments from separate sources. This enables mimiRNA to provide reliable expression profiles and to discover functional relations between miRNAs and mRNAs such as miRNA targets. Additionally, mimiRNA incorporates a decision tree algorithm to discover distinguishing miRNA features between two tissue or cell types. We validate the efficacy of our resource on independent experimental data and through biologically relevant analyses.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/mimirna.centenary.org.au<\/jats:p>\n               <jats:p>Contact: \u00a0j.rasko@centenary.org.au<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp649","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T01:13:16Z","timestamp":1258593196000},"page":"223-227","source":"Crossref","is-referenced-by-count":67,"title":["mimiRNA: a microRNA expression profiler and classification resource designed to identify functional correlations between microRNAs and their targets"],"prefix":"10.1093","volume":"26","author":[{"given":"William","family":"Ritchie","sequence":"first","affiliation":[{"name":"1 Gene and Stem Cell Therapy Program, Centenary Institute, University of Sydney, Sydney, NSW 2042 and 2 Cell and Molecular Therapies, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane","family":"Flamant","sequence":"additional","affiliation":[{"name":"1 Gene and Stem Cell Therapy Program, Centenary Institute, University of Sydney, Sydney, NSW 2042 and 2 Cell and Molecular Therapies, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E. J.","family":"Rasko","sequence":"additional","affiliation":[{"name":"1 Gene and Stem Cell Therapy Program, Centenary Institute, University of Sydney, Sydney, NSW 2042 and 2 Cell and Molecular Therapies, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown 2050, Australia"},{"name":"1 Gene and Stem Cell Therapy Program, Centenary Institute, University of Sydney, Sydney, NSW 2042 and 2 Cell and Molecular Therapies, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,11,17]]},"reference":[{"key":"2023012508203835200_B1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1472-6750-8-69","article-title":"Measuring microRNAs: comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods","volume":"8","author":"Ach","year":"2008","journal-title":"BMC Biotechnol."},{"key":"2023012508203835200_B2","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1158\/1541-7786.MCR-08-0167","article-title":"Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth","volume":"6","author":"Agirre","year":"2008","journal-title":"Mol. 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