{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:02:48Z","timestamp":1772805768519,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Rapid advances in pharmaceutical sciences have brought ever-increasing interests in combined therapies for better clinical efficacy and safety, especially in cases of complicated and refractory diseases. Innovative experimental technologies and theoretical frameworks are being actively developed for multicomponent drug research. In this work, we present the Drug Combination Database, with aims to facilitate analyses of known drug combinations, to summarize patterns of beneficial drug interactions, and to provide a basis for theoretical modeling and simulation of such drug interactions. Its current version (1.0) collected 499 approved or investigational drug combinations, including 40 unsuccessful drug combinations, involving 485 individual drugs, from &amp;gt;6000 references.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.cls.zju.edu.cn\/dcdb\/.<\/jats:p>\n               <jats:p>Contact: \u00a0xinchen@zju.edu.cn<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at the database website and Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btp697","type":"journal-article","created":{"date-parts":[[2009,12,24]],"date-time":"2009-12-24T01:52:12Z","timestamp":1261619532000},"page":"587-588","source":"Crossref","is-referenced-by-count":74,"title":["DCDB: Drug combination database"],"prefix":"10.1093","volume":"26","author":[{"given":"Yanbin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, P.R. China"}]},{"given":"Bin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, P.R. China"}]},{"given":"Chengxin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, P.R. China"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, P.R. China"}]}],"member":"286","published-online":{"date-parts":[[2009,12,23]]},"reference":[{"key":"2023012508023325100_B1","doi-asserted-by":"crossref","first-page":"7977","DOI":"10.1073\/pnas.1337088100","article-title":"Systematic discovery of multicomponent therapeutics","volume":"100","author":"Borisy","year":"2003","journal-title":"Proc. Natl Acad. Sci. 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