{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:58:19Z","timestamp":1761101899168},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: MicroRNAs (miRNAs) are involved in an abundant class of post-transcriptional regulation activated through binding to the 3\u2032 -untranslated region (UTR) of mRNAs. The current wealth of mammalian miRNA genes results mostly from genomic duplication events. Many of these events are located within introns of transcriptional units. In order to better understand the genomic expansion of miRNA genes, we investigated the distribution of intronic miRNAs.<\/jats:p>\n               <jats:p>Results: We observe that miRNA genes are hosted within introns of short genes much larger than expected by chance.<\/jats:p>\n               <jats:p>Implementation: We explore several explanations for this phenomenon and conclude that miRNA integration into short genes might be evolutionary favorable due to interaction with the pre-mRNA splicing mechanism.<\/jats:p>\n               <jats:p>Contact: \u00a0nshomron@post.tau.ac.il<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq077","type":"journal-article","created":{"date-parts":[[2010,2,26]],"date-time":"2010-02-26T01:13:25Z","timestamp":1267146805000},"page":"992-995","source":"Crossref","is-referenced-by-count":20,"title":["Biased hosting of intronic microRNA genes"],"prefix":"10.1093","volume":"26","author":[{"given":"David","family":"Golan","sequence":"first","affiliation":[{"name":"1 Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel, 2 Cutaneous Biology Research Center, Harvard Medical School, Charlestown, MA 02129 and 3 Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA"}]},{"given":"Carmit","family":"Levy","sequence":"additional","affiliation":[{"name":"1 Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel, 2 Cutaneous Biology Research Center, Harvard Medical School, Charlestown, MA 02129 and 3 Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA"}]},{"given":"Brad","family":"Friedman","sequence":"additional","affiliation":[{"name":"1 Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel, 2 Cutaneous Biology Research Center, Harvard Medical School, Charlestown, MA 02129 and 3 Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA"}]},{"given":"Noam","family":"Shomron","sequence":"additional","affiliation":[{"name":"1 Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel, 2 Cutaneous Biology Research Center, Harvard Medical School, Charlestown, MA 02129 and 3 Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA"}]}],"member":"286","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"2023012508065943200_B1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"2023012508065943200_B2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"2023012508065943200_B3","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/ng1590","article-title":"Identification of hundreds of conserved and nonconserved human microRNAs","volume":"37","author":"Bentwich","year":"2005","journal-title":"Nat. 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