{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:01:18Z","timestamp":1774954878522,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The International Union of Pure and Applied Chemistry (IUPAC) code specified nearly 25 years ago provides a nomenclature for incompletely specified nucleic acids. However, no system currently exists that allows for the informatics representation of the relative abundance at polymorphic nucleic acids (e.g. single nucleotide polymorphisms) in a single specified character, or a string of characters. Here, I propose such an information code as a natural extension to the IUPAC nomenclature code, and present some potential uses and limitations to such a code. The primary anticipated use of this extended nomenclature code is to assist in the representation of the rapidly growing space of information in human genetic variation.<\/jats:p>\n               <jats:p>Contact: \u00a0johnsonad2@nhlbi.nih.gov<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq098","type":"journal-article","created":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T01:30:02Z","timestamp":1267752602000},"page":"1386-1389","source":"Crossref","is-referenced-by-count":71,"title":["An extended IUPAC nomenclature code for polymorphic nucleic acids"],"prefix":"10.1093","volume":"26","author":[{"given":"Andrew D.","family":"Johnson","sequence":"first","affiliation":[{"name":"The National Heart, Lung and Blood Institutes' The Framingham Heart Study, Center for Population Studies, Framingham, MA 01702, USA"}]}],"member":"286","published-online":{"date-parts":[[2010,3,3]]},"reference":[{"key":"2023012507510817900_B1","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/nar\/13.9.3021","article-title":"Nomenclature for incompletely specified bases in nucleic acid sequences: recommendations 1984","volume":"13","author":"Cornish-Bowden","year":"1985","journal-title":"Nucleic Acids Res."},{"key":"2023012507510817900_B2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature07517","article-title":"Accurate whole human genome sequencing using reversible terminator chemistry","volume":"456","author":"Bentley","year":"2008","journal-title":"Nature"},{"key":"2023012507510817900_B3","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/bioinformatics\/btp319","article-title":"Data structures and compression algorithms for genomic sequence data","volume":"25","author":"Brandon","year":"2009","journal-title":"Bioinformatics"},{"key":"2023012507510817900_B4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/bioinformatics\/btn582","article-title":"Human genomes as email attachments","volume":"25","author":"Christley","year":"2009","journal-title":"Bioinformatics"},{"key":"2023012507510817900_B5","doi-asserted-by":"crossref","first-page":"R122","DOI":"10.1093\/hmg\/ddn288","article-title":"Practical aspects of imputation-driven meta-analysis of genome-wide association studies","volume":"17","author":"de Bakker","year":"2008","journal-title":"Hum. 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