{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:26:46Z","timestamp":1776317206177,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2397,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: The tissue-specific genes are a group of genes whose function and expression are preferred in one or several tissues\/cell types. Identification of these genes helps better understanding of tissue\u2013gene relationship, etiology and discovery of novel tissue-specific drug targets. In this study, a statistical method is introduced to detect tissue-specific genes from more than 123 125 gene expression profiles over 107 human tissues, 67 mouse tissues and 30 rat tissues. As a result, a novel subject-specialized repository, namely the tissue-specific genes database (TiSGeD), is developed to represent the analyzed results. Auxiliary information of tissue-specific genes was also collected from biomedical literatures.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/bioinf.xmu.edu.cn\/databases\/TiSGeD\/index.html<\/jats:p>\n               <jats:p>Contact: \u00a0appo@bioinf.xmu.edu.cn; zhiliang.ji@gmail.com<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq109","type":"journal-article","created":{"date-parts":[[2010,3,12]],"date-time":"2010-03-12T01:50:37Z","timestamp":1268358637000},"page":"1273-1275","source":"Crossref","is-referenced-by-count":149,"title":["TiSGeD: a database for tissue-specific genes"],"prefix":"10.1093","volume":"26","author":[{"given":"Sheng-Jian","family":"Xiao","sequence":"first","affiliation":[{"name":"1 Key Laboratory for Cell Biology and Tumor Cell Engineering, the Ministry of Education of China, School of Life Sciences and 2 The Key Laboratory for Chemical Biology of Fujian Province, School of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, P. R. China"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"1 Key Laboratory for Cell Biology and Tumor Cell Engineering, the Ministry of Education of China, School of Life Sciences and 2 The Key Laboratory for Chemical Biology of Fujian Province, School of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, P. R. China"}]},{"given":"Quan","family":"Zou","sequence":"additional","affiliation":[{"name":"1 Key Laboratory for Cell Biology and Tumor Cell Engineering, the Ministry of Education of China, School of Life Sciences and 2 The Key Laboratory for Chemical Biology of Fujian Province, School of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, P. R. China"}]},{"given":"Zhi-Liang","family":"Ji","sequence":"additional","affiliation":[{"name":"1 Key Laboratory for Cell Biology and Tumor Cell Engineering, the Ministry of Education of China, School of Life Sciences and 2 The Key Laboratory for Chemical Biology of Fujian Province, School of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, P. R. China"},{"name":"1 Key Laboratory for Cell Biology and Tumor Cell Engineering, the Ministry of Education of China, School of Life Sciences and 2 The Key Laboratory for Chemical Biology of Fujian Province, School of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, P. R. China"}]}],"member":"286","published-online":{"date-parts":[[2010,3,11]]},"reference":[{"key":"2023012508172109600_B1","doi-asserted-by":"crossref","first-page":"D760","DOI":"10.1093\/nar\/gkl887","article-title":"NCBI GEO: mining tens of millions of expression profiles\u2013database and tools update","volume":"35","author":"Barrett","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2023012508172109600_B2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/4478","article-title":"Gene expression informatics\u2013it's all in your mine","volume":"21","author":"Bassett","year":"1999","journal-title":"Nat. Genet."},{"key":"2023012508172109600_B3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/1471-2105-9-271","article-title":"TiGER: a database for tissue-specific gene expression and regulation","volume":"9","author":"Liu","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"2023012508172109600_B4","doi-asserted-by":"crossref","first-page":"W633","DOI":"10.1093\/nar\/gki391","article-title":"PathwayExplorer: web service for visualizing high-throughput expression data on biological pathways","volume":"33","author":"Mlecnik","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2023012508172109600_B5","doi-asserted-by":"crossref","first-page":"D628","DOI":"10.1093\/nar\/gkj137","article-title":"BodyMap-Xs: anatomical breakdown of 17 million animal ESTs for cross-species comparison of gene expression","volume":"34","author":"Ogasawara","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2023012508172109600_B6","doi-asserted-by":"crossref","first-page":"D868","DOI":"10.1093\/nar\/gkn889","article-title":"ArrayExpress update\u2013from an archive of functional genomics experiments to the atlas of gene expression","volume":"37","author":"Parkinson","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2023012508172109600_B7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1152\/physiolgenomics.00313.2005","article-title":"Detecting and profiling tissue-selective genes","volume":"26","author":"Shuang","year":"2006","journal-title":"Physiol. Genomics"},{"key":"2023012508172109600_B8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/ng1033","article-title":"From patterns to pathways: gene expression data analysis comes of age","volume":"32","author":"Slonim","year":"2002","journal-title":"Nat. Genet."},{"key":"2023012508172109600_B9","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1073\/pnas.012025199","article-title":"Large-scale analysis of the human and mouse transcriptomes","volume":"99","author":"Su","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2023012508172109600_B10","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1038\/ng1559","article-title":"Mapping of genetic and epigenetic regulatory networks using microarrays","volume":"37","author":"Van Steensel","year":"2005","journal-title":"Nat. Genet."},{"key":"2023012508172109600_B11","doi-asserted-by":"crossref","first-page":"W616","DOI":"10.1093\/nar\/gki500","article-title":"GEPAS, an experiment-oriented pipeline for the analysis of microarray gene expression data","volume":"33","author":"Vaquerizas","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2023012508172109600_B12","doi-asserted-by":"crossref","first-page":"W492","DOI":"10.1093\/nar\/gkl067","article-title":"GEPS: the Gene Expression Pattern Scanner","volume":"34","author":"Wang","year":"2006","journal-title":"Nucleic Acids Res."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/26\/9\/1273\/48857207\/bioinformatics_26_9_1273.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/26\/9\/1273\/48857207\/bioinformatics_26_9_1273.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T08:19:07Z","timestamp":1674634747000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/26\/9\/1273\/199782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,11]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btq109","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,5,1]]},"published":{"date-parts":[[2010,3,11]]}}}