{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T20:16:38Z","timestamp":1777320998803,"version":"3.51.4"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2349,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Unsupervised class discovery is a highly useful technique in cancer research, where intrinsic groups sharing biological characteristics may exist but are unknown. The consensus clustering (CC) method provides quantitative and visual stability evidence for estimating the number of unsupervised classes in a dataset. ConsensusClusterPlus implements the CC method in R and extends it with new functionality and visualizations including item tracking, item-consensus and cluster-consensus plots. These new features provide users with detailed information that enable more specific decisions in unsupervised class discovery.<\/jats:p>\n               <jats:p>Availability: ConsensusClusterPlus is open source software, written in R, under GPL-2, and available through the Bioconductor project (http:\/\/www.bioconductor.org\/).<\/jats:p>\n               <jats:p>Contact: \u00a0mwilkers@med.unc.edu<\/jats:p>\n               <jats:p>Supplementary Information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq170","type":"journal-article","created":{"date-parts":[[2010,4,29]],"date-time":"2010-04-29T02:34:16Z","timestamp":1272508456000},"page":"1572-1573","source":"Crossref","is-referenced-by-count":4660,"title":["ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking"],"prefix":"10.1093","volume":"26","author":[{"given":"Matthew D.","family":"Wilkerson","sequence":"first","affiliation":[{"name":"1 Lineberger Comprehensive Cancer Center and 2 Department of Internal Medicine, Division of Medical Oncology, Multidisciplinary Thoracic Oncology Program, 450 West Drive, Campus Box 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}]},{"given":"D. Neil","family":"Hayes","sequence":"additional","affiliation":[{"name":"1 Lineberger Comprehensive Cancer Center and 2 Department of Internal Medicine, Division of Medical Oncology, Multidisciplinary Thoracic Oncology Program, 450 West Drive, Campus Box 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"},{"name":"1 Lineberger Comprehensive Cancer Center and 2 Department of Internal Medicine, Division of Medical Oncology, Multidisciplinary Thoracic Oncology Program, 450 West Drive, Campus Box 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}]}],"member":"286","published-online":{"date-parts":[[2010,4,28]]},"reference":[{"key":"2023012508043861500_B1","doi-asserted-by":"crossref","first-page":"13784","DOI":"10.1073\/pnas.241500798","article-title":"Diversity of gene expression in adenocarcinoma of the lung","volume":"98","author":"Garber","year":"2001","journal-title":"Proc. Natl Acad. Sci. 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