{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:22:09Z","timestamp":1767918129923,"version":"3.49.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2337,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Epigenetics, the study of heritable somatic phenotypic changes not related to DNA sequence, has emerged as a critical component of the landscape of gene regulation. The epigenetic layers, such as DNA methylation, histone modifications and nuclear architecture are now being extensively studied in many cell types and disease settings. Few software tools exist to summarize and interpret these datasets. We have created a toolbox of procedures to interrogate and visualize epigenomic data (both array- and sequencing-based) and make available a software package for the cross-platform R language.<\/jats:p>\n               <jats:p>Availability: The package is freely available under LGPL from the R-Forge web site (http:\/\/repitools.r-forge.r-project.org\/)<\/jats:p>\n               <jats:p>Contact: \u00a0mrobinson@wehi.edu.au<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq247","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T02:53:49Z","timestamp":1273546429000},"page":"1662-1663","source":"Crossref","is-referenced-by-count":66,"title":["<tt>Repitools<\/tt>: an R package for the analysis of enrichment-based epigenomic data"],"prefix":"10.1093","volume":"26","author":[{"given":"Aaron L.","family":"Statham","sequence":"first","affiliation":[{"name":"1 Epigenetics Laboratory, Cancer Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, 2 St Vincent's Clinical School, The University of New South Wales, NSW 2052 and 3 Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia"}]},{"given":"Dario","family":"Strbenac","sequence":"additional","affiliation":[{"name":"1 Epigenetics Laboratory, Cancer Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, 2 St Vincent's Clinical School, The University of New South Wales, NSW 2052 and 3 Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia"}]},{"given":"Marcel W.","family":"Coolen","sequence":"additional","affiliation":[{"name":"1 Epigenetics Laboratory, Cancer Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, 2 St Vincent's Clinical School, The University of New South Wales, NSW 2052 and 3 Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia"}]},{"given":"Clare","family":"Stirzaker","sequence":"additional","affiliation":[{"name":"1 Epigenetics Laboratory, Cancer Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, 2 St Vincent's Clinical School, The University of New South Wales, NSW 2052 and 3 Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia"}]},{"given":"Susan J.","family":"Clark","sequence":"additional","affiliation":[{"name":"1 Epigenetics Laboratory, Cancer Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, 2 St Vincent's Clinical School, The University of New South Wales, NSW 2052 and 3 Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia"},{"name":"1 Epigenetics Laboratory, Cancer Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, 2 St Vincent's Clinical School, The University of New South Wales, NSW 2052 and 3 Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia"}]},{"given":"Mark D.","family":"Robinson","sequence":"additional","affiliation":[{"name":"1 Epigenetics Laboratory, Cancer Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, 2 St Vincent's Clinical School, The University of New South Wales, NSW 2052 and 3 Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia"},{"name":"1 Epigenetics Laboratory, Cancer Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, 2 St Vincent's Clinical School, The University of New South Wales, NSW 2052 and 3 Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia"}]}],"member":"286","published-online":{"date-parts":[[2010,5,10]]},"reference":[{"key":"2023012507552178900_B1","article-title":"aroma.affymetrix: a generic framework in R for analyzing small to very large Affymetrix data sets in bounded memory","volume-title":"Technical Report #745","author":"Bengtsson","year":"2008"},{"key":"2023012507552178900_B2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ncb2023","article-title":"Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity","volume":"12","author":"Coolen","year":"2010","journal-title":"Nat. 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