{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:37:22Z","timestamp":1761561442954},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2280,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: We present the first parallel implementation of the T-Coffee consistency-based multiple aligner. We benchmark it on the Amazon Elastic Cloud (EC2) and show that the parallelization procedure is reasonably effective. We also conclude that for a web server with moderate usage (10K hits\/month) the cloud provides a cost-effective alternative to in-house deployment.<\/jats:p>\n               <jats:p>Availability: T-Coffee is a freeware open source package available from http:\/\/www.tcoffee.org\/homepage.html<\/jats:p>\n               <jats:p>Contact: \u00a0cedric.notredame@crg.es<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq304","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T01:15:32Z","timestamp":1278465332000},"page":"1903-1904","source":"Crossref","is-referenced-by-count":25,"title":["Cloud-Coffee: implementation of a parallel consistency-based multiple alignment algorithm in the T-Coffee package and its benchmarking on the Amazon Elastic-Cloud"],"prefix":"10.1093","volume":"26","author":[{"given":"Paolo","family":"Di Tommaso","sequence":"first","affiliation":[{"name":"1 Centre For Genomic Regulation (Pompeu Fabra University), Carrer del Doctor Aiguader 88, 08003 Barcelona, 2Department of Computer Science and Industrial Engineering, University of Lleida, Campus de Cappont, C. de Jaume II 69, E-25001 Lleida and 3Department of Computer Architecture and Operating Systems, Universitad Autonoma de Barcelona, Campus UAB, Edifici Q, 08193 Bellaterra (Barcelona), Spain"}]},{"given":"Miquel","family":"Orobitg","sequence":"additional","affiliation":[{"name":"1 Centre For Genomic Regulation (Pompeu Fabra University), Carrer del Doctor Aiguader 88, 08003 Barcelona, 2Department of Computer Science and Industrial Engineering, University of Lleida, Campus de Cappont, C. de Jaume II 69, E-25001 Lleida and 3Department of Computer Architecture and Operating Systems, Universitad Autonoma de Barcelona, Campus UAB, Edifici Q, 08193 Bellaterra (Barcelona), Spain"}]},{"given":"Fernando","family":"Guirado","sequence":"additional","affiliation":[{"name":"1 Centre For Genomic Regulation (Pompeu Fabra University), Carrer del Doctor Aiguader 88, 08003 Barcelona, 2Department of Computer Science and Industrial Engineering, University of Lleida, Campus de Cappont, C. de Jaume II 69, E-25001 Lleida and 3Department of Computer Architecture and Operating Systems, Universitad Autonoma de Barcelona, Campus UAB, Edifici Q, 08193 Bellaterra (Barcelona), Spain"}]},{"given":"Fernado","family":"Cores","sequence":"additional","affiliation":[{"name":"1 Centre For Genomic Regulation (Pompeu Fabra University), Carrer del Doctor Aiguader 88, 08003 Barcelona, 2Department of Computer Science and Industrial Engineering, University of Lleida, Campus de Cappont, C. de Jaume II 69, E-25001 Lleida and 3Department of Computer Architecture and Operating Systems, Universitad Autonoma de Barcelona, Campus UAB, Edifici Q, 08193 Bellaterra (Barcelona), Spain"}]},{"given":"Toni","family":"Espinosa","sequence":"additional","affiliation":[{"name":"1 Centre For Genomic Regulation (Pompeu Fabra University), Carrer del Doctor Aiguader 88, 08003 Barcelona, 2Department of Computer Science and Industrial Engineering, University of Lleida, Campus de Cappont, C. de Jaume II 69, E-25001 Lleida and 3Department of Computer Architecture and Operating Systems, Universitad Autonoma de Barcelona, Campus UAB, Edifici Q, 08193 Bellaterra (Barcelona), Spain"}]},{"given":"Cedric","family":"Notredame","sequence":"additional","affiliation":[{"name":"1 Centre For Genomic Regulation (Pompeu Fabra University), Carrer del Doctor Aiguader 88, 08003 Barcelona, 2Department of Computer Science and Industrial Engineering, University of Lleida, Campus de Cappont, C. de Jaume II 69, E-25001 Lleida and 3Department of Computer Architecture and Operating Systems, Universitad Autonoma de Barcelona, Campus UAB, Edifici Q, 08193 Bellaterra (Barcelona), Spain"}]}],"member":"286","published-online":{"date-parts":[[2010,7,6]]},"reference":[{"key":"2023012507594982700_B1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1101\/gr.2821705","article-title":"ProbCons: probabilistic consistency-based multiple sequence alignment","volume":"15","author":"Do","year":"2005","journal-title":"Genome Res."},{"key":"2023012507594982700_B2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/nar\/gkh180","article-title":"Local homology recognition and distance measures in linear time using compressed amino acid alphabets","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2023012507594982700_B3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.sbi.2006.04.004","article-title":"Multiple sequence alignment","volume":"16","author":"Edgar","year":"2006","journal-title":"Curr. 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