{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:14:35Z","timestamp":1787008475158,"version":"build-2736575974"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different levels of detail. This makes comparative and cross-talk analyses difficult.<\/jats:p>\n                  <jats:p>Results: We present SignaLink, a database containing eight major signaling pathways from Caenorhabditis elegans, Drosophila melanogaster and humans. Based on 170 review and \u223c800 research articles, we have compiled pathways with semi-automatic searches and uniform, well-documented curation rules. We found that in humans any two of the eight pathways can cross-talk. We quantified the possible tissue- and cancer-specific activity of cross-talks and found pathway-specific expression profiles. In addition, we identified 327 proteins relevant for drug target discovery.<\/jats:p>\n                  <jats:p>Conclusions: We provide a novel resource for comparative and cross-talk analyses of signaling pathways. The identified multi-pathway and tissue-specific cross-talks contribute to the understanding of the signaling complexity in health and disease, and underscore its importance in network-based drug target selection.<\/jats:p>\n                  <jats:p>Availability: \u00a0http:\/\/SignaLink.org<\/jats:p>\n                  <jats:p>Contact: \u00a0csermely@eok.sote.hu<\/jats:p>\n                  <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq310","type":"journal-article","created":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T20:25:02Z","timestamp":1276287902000},"page":"2042-2050","source":"Crossref","is-referenced-by-count":68,"title":["Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery"],"prefix":"10.1093","volume":"26","author":[{"given":"Tam\u00e1s","family":"Korcsm\u00e1ros","sequence":"first","affiliation":[{"name":"1 Department of Genetics, E\u00f6tv\u00f6s University, P\u00e1zm\u00e1ny P. s. 1C, H-1117 Budapest, 2Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest, 3Statistical and Biological Physics Group of the Hungarian Academy of Sciences, P\u00e1zm\u00e1ny P. s. 1A, H-1117 Budapest, 4Morgan Stanley Hungary Analytics Ltd., Lechner \u00d6. f. 8, H-1095 Budapest and 5Department of Morphology and Physiology, Semmelweis University, Vas u. 17, H-1088 Budapest, Hungary"},{"name":"1 Department of Genetics, E\u00f6tv\u00f6s University, P\u00e1zm\u00e1ny P. s. 1C, H-1117 Budapest, 2Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest, 3Statistical and Biological Physics Group of the Hungarian Academy of Sciences, P\u00e1zm\u00e1ny P. s. 1A, H-1117 Budapest, 4Morgan Stanley Hungary Analytics Ltd., Lechner \u00d6. f. 8, H-1095 Budapest and 5Department of Morphology and Physiology, Semmelweis University, Vas u. 17, H-1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ill\u00e9s J.","family":"Farkas","sequence":"additional","affiliation":[{"name":"1 Department of Genetics, E\u00f6tv\u00f6s University, P\u00e1zm\u00e1ny P. s. 1C, H-1117 Budapest, 2Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest, 3Statistical and Biological Physics Group of the Hungarian Academy of Sciences, P\u00e1zm\u00e1ny P. s. 1A, H-1117 Budapest, 4Morgan Stanley Hungary Analytics Ltd., Lechner \u00d6. f. 8, H-1095 Budapest and 5Department of Morphology and Physiology, Semmelweis University, Vas u. 17, H-1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1t\u00e9 S.","family":"Szalay","sequence":"additional","affiliation":[{"name":"1 Department of Genetics, E\u00f6tv\u00f6s University, P\u00e1zm\u00e1ny P. s. 1C, H-1117 Budapest, 2Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest, 3Statistical and Biological Physics Group of the Hungarian Academy of Sciences, P\u00e1zm\u00e1ny P. s. 1A, H-1117 Budapest, 4Morgan Stanley Hungary Analytics Ltd., Lechner \u00d6. f. 8, H-1095 Budapest and 5Department of Morphology and Physiology, Semmelweis University, Vas u. 17, H-1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Rov\u00f3","sequence":"additional","affiliation":[{"name":"1 Department of Genetics, E\u00f6tv\u00f6s University, P\u00e1zm\u00e1ny P. s. 1C, H-1117 Budapest, 2Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest, 3Statistical and Biological Physics Group of the Hungarian Academy of Sciences, P\u00e1zm\u00e1ny P. s. 1A, H-1117 Budapest, 4Morgan Stanley Hungary Analytics Ltd., Lechner \u00d6. f. 8, H-1095 Budapest and 5Department of Morphology and Physiology, Semmelweis University, Vas u. 17, H-1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1vid","family":"Fazekas","sequence":"additional","affiliation":[{"name":"1 Department of Genetics, E\u00f6tv\u00f6s University, P\u00e1zm\u00e1ny P. s. 1C, H-1117 Budapest, 2Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest, 3Statistical and Biological Physics Group of the Hungarian Academy of Sciences, P\u00e1zm\u00e1ny P. s. 1A, H-1117 Budapest, 4Morgan Stanley Hungary Analytics Ltd., Lechner \u00d6. f. 8, H-1095 Budapest and 5Department of Morphology and Physiology, Semmelweis University, Vas u. 17, H-1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Spir\u00f3","sequence":"additional","affiliation":[{"name":"1 Department of Genetics, E\u00f6tv\u00f6s University, P\u00e1zm\u00e1ny P. s. 1C, H-1117 Budapest, 2Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest, 3Statistical and Biological Physics Group of the Hungarian Academy of Sciences, P\u00e1zm\u00e1ny P. s. 1A, H-1117 Budapest, 4Morgan Stanley Hungary Analytics Ltd., Lechner \u00d6. f. 8, H-1095 Budapest and 5Department of Morphology and Physiology, Semmelweis University, Vas u. 17, H-1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"B\u00f6de","sequence":"additional","affiliation":[{"name":"1 Department of Genetics, E\u00f6tv\u00f6s University, P\u00e1zm\u00e1ny P. s. 1C, H-1117 Budapest, 2Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest, 3Statistical and Biological Physics Group of the Hungarian Academy of Sciences, P\u00e1zm\u00e1ny P. s. 1A, H-1117 Budapest, 4Morgan Stanley Hungary Analytics Ltd., Lechner \u00d6. f. 8, H-1095 Budapest and 5Department of Morphology and Physiology, Semmelweis University, Vas u. 17, H-1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Lenti","sequence":"additional","affiliation":[{"name":"1 Department of Genetics, E\u00f6tv\u00f6s University, P\u00e1zm\u00e1ny P. s. 1C, H-1117 Budapest, 2Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest, 3Statistical and Biological Physics Group of the Hungarian Academy of Sciences, P\u00e1zm\u00e1ny P. s. 1A, H-1117 Budapest, 4Morgan Stanley Hungary Analytics Ltd., Lechner \u00d6. f. 8, H-1095 Budapest and 5Department of Morphology and Physiology, Semmelweis University, Vas u. 17, H-1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Vellai","sequence":"additional","affiliation":[{"name":"1 Department of Genetics, E\u00f6tv\u00f6s University, P\u00e1zm\u00e1ny P. s. 1C, H-1117 Budapest, 2Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest, 3Statistical and Biological Physics Group of the Hungarian Academy of Sciences, P\u00e1zm\u00e1ny P. s. 1A, H-1117 Budapest, 4Morgan Stanley Hungary Analytics Ltd., Lechner \u00d6. f. 8, H-1095 Budapest and 5Department of Morphology and Physiology, Semmelweis University, Vas u. 17, H-1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Csermely","sequence":"additional","affiliation":[{"name":"1 Department of Genetics, E\u00f6tv\u00f6s University, P\u00e1zm\u00e1ny P. s. 1C, H-1117 Budapest, 2Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest, 3Statistical and Biological Physics Group of the Hungarian Academy of Sciences, P\u00e1zm\u00e1ny P. s. 1A, H-1117 Budapest, 4Morgan Stanley Hungary Analytics Ltd., Lechner \u00d6. f. 8, H-1095 Budapest and 5Department of Morphology and Physiology, Semmelweis University, Vas u. 17, H-1088 Budapest, 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