{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T17:45:01Z","timestamp":1747417501425},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Quantifying differences in linkage disequilibrium (LD) between sub-groups can highlight genetic regions or sites under selection and\/or associated with disease, and may have utility in trans-ethnic mapping studies.<\/jats:p>\n               <jats:p>Results: We present a novel pseudo Bayes factor (PBF) approach that assess differences in covariance of genotype frequencies from single nucleotide polymorphism (SNP) data from a genome-wide study. The magnitude of the PBF reflects the strength of evidence for a difference, while accounting for the sample size and number of SNPs, without the requirement for permutation testing to establish statistical significance. Application of the PBF to HapMap and Gambian malaria SNP data reveals regional LD differences, some known to be under selection.<\/jats:p>\n               <jats:p>Availability and implementation: The PBF approach has been implemented in the BALD (Bayesian analysis of LD differences) C++ software, and is available from http:\/\/homepages.lshtm.ac.uk\/tgclark\/downloads<\/jats:p>\n               <jats:p>Contact: \u00a0taane.clark@lshtm.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq327","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T01:00:02Z","timestamp":1276736402000},"page":"1999-2003","source":"Crossref","is-referenced-by-count":6,"title":["A Bayesian approach using covariance of single nucleotide polymorphism data to detect differences in linkage disequilibrium patterns between groups of individuals"],"prefix":"10.1093","volume":"26","author":[{"given":"Taane G.","family":"Clark","sequence":"first","affiliation":[{"name":"1 Departments of Epidemiology and Public Health and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, 2Wellcome Trust Sanger Institute, Hinxton, Cambridge, 3Wellcome Trust Centre for Human Genetics, University of Oxford and 4Department of Statistics, University of Oxford, Oxford, UK"},{"name":"1 Departments of Epidemiology and Public Health and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, 2Wellcome Trust Sanger Institute, Hinxton, Cambridge, 3Wellcome Trust Centre for Human Genetics, University of Oxford and 4Department of Statistics, University of Oxford, Oxford, UK"}]},{"given":"Susana G.","family":"Campino","sequence":"additional","affiliation":[{"name":"1 Departments of Epidemiology and Public Health and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, 2Wellcome Trust Sanger Institute, Hinxton, Cambridge, 3Wellcome Trust Centre for Human Genetics, University of Oxford and 4Department of Statistics, University of Oxford, Oxford, UK"}]},{"given":"Elisa","family":"Anastasi","sequence":"additional","affiliation":[{"name":"1 Departments of Epidemiology and Public Health and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, 2Wellcome Trust Sanger Institute, Hinxton, Cambridge, 3Wellcome Trust Centre for Human Genetics, University of Oxford and 4Department of Statistics, University of Oxford, Oxford, UK"}]},{"given":"Sarah","family":"Auburn","sequence":"additional","affiliation":[{"name":"1 Departments of Epidemiology and Public Health and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, 2Wellcome Trust Sanger Institute, Hinxton, Cambridge, 3Wellcome Trust Centre for Human Genetics, University of Oxford and 4Department of Statistics, University of Oxford, Oxford, UK"}]},{"given":"Yik Y.","family":"Teo","sequence":"additional","affiliation":[{"name":"1 Departments of Epidemiology and Public Health and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, 2Wellcome Trust Sanger Institute, Hinxton, Cambridge, 3Wellcome Trust Centre for Human Genetics, University of Oxford and 4Department of Statistics, University of Oxford, Oxford, UK"}]},{"given":"Kerrin","family":"Small","sequence":"additional","affiliation":[{"name":"1 Departments of Epidemiology and Public Health and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, 2Wellcome Trust Sanger Institute, Hinxton, Cambridge, 3Wellcome Trust Centre for Human Genetics, University of Oxford and 4Department of Statistics, University of Oxford, Oxford, UK"}]},{"given":"Kirk A.","family":"Rockett","sequence":"additional","affiliation":[{"name":"1 Departments of Epidemiology and Public Health and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, 2Wellcome Trust Sanger Institute, Hinxton, Cambridge, 3Wellcome Trust Centre for Human Genetics, University of Oxford and 4Department of Statistics, University of Oxford, Oxford, UK"}]},{"given":"Dominic P.","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"1 Departments of Epidemiology and Public Health and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, 2Wellcome Trust Sanger Institute, Hinxton, Cambridge, 3Wellcome Trust Centre for Human Genetics, University of Oxford and 4Department of Statistics, University of Oxford, Oxford, UK"},{"name":"1 Departments of Epidemiology and Public Health and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, 2Wellcome Trust Sanger Institute, Hinxton, Cambridge, 3Wellcome Trust Centre for Human Genetics, University of Oxford and 4Department of Statistics, University of Oxford, Oxford, UK"}]},{"given":"Christopher C.","family":"Holmes","sequence":"additional","affiliation":[{"name":"1 Departments of Epidemiology and Public Health and Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, 2Wellcome Trust Sanger Institute, Hinxton, Cambridge, 3Wellcome Trust Centre for Human Genetics, University of Oxford and 4Department of Statistics, University of Oxford, Oxford, UK"}]}],"member":"286","published-online":{"date-parts":[[2010,6,16]]},"reference":[{"issue":"Suppl. 1","key":"2023012508020228500_B1","first-page":"560","article-title":"Maximum identity length contrast: a powerful method for susceptibility gene detection in isolated populations","volume":"21","author":"Bourgain","year":"2001","journal-title":"Eur. 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