{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:25:07Z","timestamp":1772015107614,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2273,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Computational methods designed to discover transcription factor binding sites in DNA sequences often have a tendency to make a lot of false predictions. One way to improve accuracy in motif discovery is to rely on positional priors to focus the search to parts of a sequence that are considered more likely to contain functional binding sites. We present here a program called PriorsEditor that can be used to create such positional priors tracks based on a combination of several features, including phylogenetic conservation, nucleosome occupancy, histone modifications, physical properties of the DNA helix and many more.<\/jats:p>\n               <jats:p>Availability: PriorsEditor is available as a web start application and downloadable archive from http:\/\/tare.medisin.ntnu.no\/priorseditor (requires Java 1.6). The web site also provides tutorials, screenshots and example protocol scripts.<\/jats:p>\n               <jats:p>Contact: \u00a0kjetil.klepper@ntnu.no<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq357","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T02:24:06Z","timestamp":1279074246000},"page":"2195-2197","source":"Crossref","is-referenced-by-count":7,"title":["PriorsEditor: a tool for the creation and use of positional priors in motif discovery"],"prefix":"10.1093","volume":"26","author":[{"given":"Kjetil","family":"Klepper","sequence":"first","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn","family":"Drabl\u00f8s","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,7,13]]},"reference":[{"key":"2023012508013351000_B1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/1471-2105-11-179","article-title":"The value of position-specific priors in motif discovery using MEME","volume":"11","author":"Bailey","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2023012508013351000_B2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1186\/1471-2164-8-459","article-title":"Positional bias of general and tissue-specific regulatory motifs in mouse gene promoters","volume":"8","author":"Bellora","year":"2007","journal-title":"BMC Genomics"},{"key":"2023012508013351000_B3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0959-440X(97)80058-9","article-title":"Searching for regulatory elements in human noncoding sequences","volume":"7","author":"Duret","year":"1997","journal-title":"Curr. 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