{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:26:36Z","timestamp":1773329196770,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2220,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Motivation: Identifying drug\u2013drug interactions (DDIs) is a critical process in drug administration and drug development. Clinical support tools often provide comprehensive lists of DDIs, but they usually lack the supporting scientific evidences and different tools can return inconsistent results. In this article, we propose a novel approach that integrates text mining and automated reasoning to derive DDIs. Through the extraction of various facts of drug metabolism, not only the DDIs that are explicitly mentioned in text can be extracted but also the potential interactions that can be inferred by reasoning.<\/jats:p><jats:p>Results: Our approach was able to find several potential DDIs that are not present in DrugBank. We manually evaluated these interactions based on their supporting evidences, and our analysis revealed that 81.3% of these interactions are determined to be correct. This suggests that our approach can uncover potential DDIs with scientific evidences explaining the mechanism of the interactions.<\/jats:p><jats:p>Contact: \u00a0luis.tari@roche.com<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq382","type":"journal-article","created":{"date-parts":[[2010,9,7]],"date-time":"2010-09-07T17:41:46Z","timestamp":1283881306000},"page":"i547-i553","source":"Crossref","is-referenced-by-count":121,"title":["Discovering drug\u2013drug interactions: a text-mining and reasoning approach based on properties of drug metabolism"],"prefix":"10.1093","volume":"26","author":[{"given":"Luis","family":"Tari","sequence":"first","affiliation":[{"name":"1 Disease and Translational Informatics, Hoffmann-La Roche, Nutley, NJ 07110 and 2Department of Computer Science and Engineering, Arizona State University, Tempe, AZ 85287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saadat","family":"Anwar","sequence":"additional","affiliation":[{"name":"1 Disease and Translational Informatics, Hoffmann-La Roche, Nutley, NJ 07110 and 2Department of Computer Science and Engineering, Arizona State University, Tempe, AZ 85287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Liang","sequence":"additional","affiliation":[{"name":"1 Disease and Translational Informatics, Hoffmann-La Roche, Nutley, NJ 07110 and 2Department of Computer Science and Engineering, Arizona State University, Tempe, AZ 85287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Cai","sequence":"additional","affiliation":[{"name":"1 Disease and Translational Informatics, Hoffmann-La Roche, Nutley, NJ 07110 and 2Department of Computer Science and Engineering, Arizona State University, Tempe, AZ 85287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitta","family":"Baral","sequence":"additional","affiliation":[{"name":"1 Disease and Translational Informatics, Hoffmann-La Roche, Nutley, NJ 07110 and 2Department of Computer Science and Engineering, Arizona State University, Tempe, AZ 85287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,9,4]]},"reference":[{"key":"2023012508262909100_B1","article-title":"MetaMap: Mapping Text to the UMLS Metathesaurus","author":"Aronson","year":"1996","journal-title":"NLM, NIH, DHHS."},{"key":"2023012508262909100_B2","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511543357","volume-title":"Knowledge Representation, Reasoning and Declarative Problem Solving.","author":"Baral","year":"2003"},{"key":"2023012508262909100_B3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/10837450902891550","article-title":"Drug interactions","volume":"41","author":"Boobis","year":"2009","journal-title":"Drug Metab. 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