{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T05:20:25Z","timestamp":1674710425102},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2253,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Mathematical models of biological systems often have a large number of parameters whose combinational variations can yield distinct qualitative behaviors. Since it is intractable to examine all possible combinations of parameters for non-trivial biological pathways, it is required to have a systematic strategy to explore the parameter space in a computational way so that dynamic behaviors of a given pathway are estimated.<\/jats:p>\n               <jats:p>Results: We present PSExplorer, a computational tool for exploring qualitative behaviors and key parameters of molecular signaling pathways. Utilizing the Latin hypercube sampling and a clustering technique in a recursive paradigm, the software enables users to explore the whole parameter space of the models to search for robust qualitative behaviors. The parameter space is partitioned into sub-regions according to behavioral differences. Sub-regions showing robust behaviors can be identified for further analyses. The partitioning result presents a tree structure from which individual and combinational effects of parameters on model behaviors can be assessed and key factors of the models are readily identified.<\/jats:p>\n               <jats:p>Availability: The software, tutorial manual and test models are available for download at the following address: http:\/\/gto.kaist.ac.kr\/\u223cpsexplorer<\/jats:p>\n               <jats:p>Contact: \u00a0tqtung@kaist.ac.kr; tqtung@gmail.com<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq440","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T03:30:44Z","timestamp":1280806244000},"page":"2477-2479","source":"Crossref","is-referenced-by-count":0,"title":["PSExplorer: whole parameter space exploration for molecular signaling pathway dynamics"],"prefix":"10.1093","volume":"26","author":[{"given":"Thai Quang","family":"Tung","sequence":"first","affiliation":[{"name":"1Department of Bio and Brain Engineering, KAIST 373\u20131 Guseong-dong, Yuseong-gu, Daejeon 305\u2013701, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doheon","family":"Lee","sequence":"additional","affiliation":[{"name":"1Department of Bio and Brain Engineering, KAIST 373\u20131 Guseong-dong, Yuseong-gu, Daejeon 305\u2013701, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,8,2]]},"reference":[{"key":"2023012508172004000_B1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/jtbi.1998.0781","article-title":"Bifurcation analysis of a model of mitotic control in frog eggs","volume":"195","author":"Borisuk","year":"1998","journal-title":"J. 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