{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:22:05Z","timestamp":1761862925702},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: SPRINT is a software package that performs computational multistate protein design using state-of-the-art inference on probabilistic graphical models. The input to SPRINT is a list of protein structures, the rotamers modeled for each structure and the pre-calculated rotamer energies. Probabilistic inference is performed using the belief propagation or A* algorithms, and dead-end elimination can be applied as pre-processing. The output can either be a list of amino acid sequences simultaneously compatible with these structures, or probabilistic amino acid profiles compatible with the structures. In addition, higher order (e.g. pairwise) amino acid probabilities can also be predicted. Finally, SPRINT also has a module for protein side-chain prediction and single-state design.<\/jats:p>\n               <jats:p>Availability: The full C++ source code for SPRINT can be freely downloaded from http:\/\/www.protonet.cs.huji.ac.il\/sprint<\/jats:p>\n               <jats:p>Contact: \u00a0fromer@cs.huji.ac.il<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq445","type":"journal-article","created":{"date-parts":[[2010,8,5]],"date-time":"2010-08-05T03:27:36Z","timestamp":1280978856000},"page":"2466-2467","source":"Crossref","is-referenced-by-count":10,"title":["SPRINT: side-chain prediction inference toolbox for multistate protein design"],"prefix":"10.1093","volume":"26","author":[{"given":"Menachem","family":"Fromer","sequence":"first","affiliation":[{"name":"1 School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel, 2Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA and 3Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel"}]},{"given":"Chen","family":"Yanover","sequence":"additional","affiliation":[{"name":"1 School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel, 2Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA and 3Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel"}]},{"given":"Amir","family":"Harel","sequence":"additional","affiliation":[{"name":"1 School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel, 2Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA and 3Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel"}]},{"given":"Ori","family":"Shachar","sequence":"additional","affiliation":[{"name":"1 School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel, 2Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA and 3Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel"}]},{"given":"Yair","family":"Weiss","sequence":"additional","affiliation":[{"name":"1 School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel, 2Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA and 3Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel"}]},{"given":"Michal","family":"Linial","sequence":"additional","affiliation":[{"name":"1 School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel, 2Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA and 3Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel"}]}],"member":"286","published-online":{"date-parts":[[2010,8,4]]},"reference":[{"key":"2023012508171578200_B1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1021\/ja054718w","article-title":"Computational design of a single amino acid sequence that can switch between two distinct protein folds","volume":"128","author":"Ambroggio","year":"2006","journal-title":"J. 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