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Our findings on breast cancer data replicate previous results and shed light on variant effects within genes.<\/jats:p><jats:p>Availability: Rare variant discovery by group penalized regression is now implemented in the free program Mendel at http:\/\/www.genetics.ucla.edu\/software\/<\/jats:p><jats:p>Contact: \u00a0huazhou@ucla.edu<\/jats:p><jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq448","type":"journal-article","created":{"date-parts":[[2010,8,7]],"date-time":"2010-08-07T02:17:53Z","timestamp":1281147473000},"page":"2375-2382","source":"Crossref","is-referenced-by-count":107,"title":["Association screening of common and rare genetic variants by penalized regression"],"prefix":"10.1093","volume":"26","author":[{"given":"Hua","family":"Zhou","sequence":"first","affiliation":[{"name":"1 Department of Statistics, North Carolina State University, Raleigh, NC 27695\u22128203, 2Departments of Human Genetics, 3Departments of Medicine, 4Departments of Biomathematics, 5Departments of Biostatistics and 6Departments of Statistics, University of California, Los Angeles, CA 90095, USA"},{"name":"1 Department of Statistics, North Carolina State University, Raleigh, NC 27695\u22128203, 2Departments of Human Genetics, 3Departments of Medicine, 4Departments of Biomathematics, 5Departments of Biostatistics and 6Departments of Statistics, University of California, Los Angeles, CA 90095, USA"}]},{"given":"Mary E.","family":"Sehl","sequence":"additional","affiliation":[{"name":"1 Department of Statistics, North Carolina State University, Raleigh, NC 27695\u22128203, 2Departments of Human Genetics, 3Departments of Medicine, 4Departments of Biomathematics, 5Departments of Biostatistics and 6Departments of Statistics, University of California, Los Angeles, CA 90095, USA"}]},{"given":"Janet S.","family":"Sinsheimer","sequence":"additional","affiliation":[{"name":"1 Department of 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