{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:09:51Z","timestamp":1773857391972,"version":"3.50.1"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2229,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Gene coexpression analysis was developed to explore gene interconnection at the expression level from a systems perspective, and differential coexpression analysis (DCEA), which examines the change in gene expression correlation between two conditions, was accordingly designed as a complementary technique to traditional differential expression analysis (DEA). Since there is a shortage of DCEA tools, we implemented in an R package \u2018DCGL\u2019 five DCEA methods for identification of differentially coexpressed genes and differentially coexpressed links, including three currently popular methods and two novel algorithms described in a companion paper. DCGL can serve as an easy-to-use tool to facilitate differential coexpression analyses.<\/jats:p>\n               <jats:p>Contact: \u00a0yyli@scbit.org and yxli@scbit.org<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq471","type":"journal-article","created":{"date-parts":[[2010,8,28]],"date-time":"2010-08-28T00:40:38Z","timestamp":1282956038000},"page":"2637-2638","source":"Crossref","is-referenced-by-count":81,"title":["DCGL: an R package for identifying differentially coexpressed genes and links from gene expression microarray data"],"prefix":"10.1093","volume":"26","author":[{"given":"Bao-Hong","family":"Liu","sequence":"first","affiliation":[{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"},{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"},{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"},{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"}]},{"given":"Kang","family":"Tu","sequence":"additional","affiliation":[{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"}]},{"given":"Yi-Xue","family":"Li","sequence":"additional","affiliation":[{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"},{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"},{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"}]},{"given":"Yuan-Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"},{"name":"1 School of Life Science and Technology, Tongji University, Shanghai 200092, 2Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 3Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China, 4National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 30105 and 5Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"}]}],"member":"286","published-online":{"date-parts":[[2010,8,26]]},"reference":[{"key":"2023012507555795600_B1","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1093\/bioinformatics\/bti722","article-title":"Differential coexpression analysis using microarray data and its application to human cancer","volume":"21","author":"Choi","year":"2005","journal-title":"Bioinformatics"},{"key":"2023012507555795600_B2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/1471-2164-10-327","article-title":"Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells","volume":"10","author":"Mason","year":"2009","journal-title":"BMC Genomics"},{"key":"2023012507555795600_B3","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1093\/bioinformatics\/btl392","article-title":"Simultaneous identification of differential gene expression and connectivity in inflammation, adipogenesis and cancer","volume":"22","author":"Reverter","year":"2006","journal-title":"Bioinformatics"},{"key":"2023012507555795600_B4","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1210\/en.2008-0563","article-title":"Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks","volume":"150","author":"van Nas","year":"2009","journal-title":"Endocrinology"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/26\/20\/2637\/48852321\/bioinformatics_26_20_2637.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/26\/20\/2637\/48852321\/bioinformatics_26_20_2637.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T07:56:29Z","timestamp":1674633389000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/26\/20\/2637\/193954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,26]]},"references-count":4,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2010,10,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btq471","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,10,15]]},"published":{"date-parts":[[2010,8,26]]}}}