{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T05:20:28Z","timestamp":1674710428261},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2203,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: SpotXplore is a plugin for Cytoscape for extraction and visualization of differentially expressed subnetworks (hotspots) from gene networks. The hotspot-based visualization approach enables interactive exploration of regulatory interactions in differentially expressed gene sets, and it allows a researcher to explore gene expression in direct relation to the affected cellular gene network. The hotspots provide a view beyond the commonly used metabolic pathways and gene ontologies.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.win.tue.nl\/\u223cmwestenb\/spotxplore\/<\/jats:p>\n               <jats:p>Contact: \u00a0m.a.westenberg@tue.nl<\/jats:p>\n               <jats:p>Supplementary information: Example data and user manual are available at SpotXplore's web site.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq535","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T00:31:47Z","timestamp":1285201907000},"page":"2922-2923","source":"Crossref","is-referenced-by-count":6,"title":["SpotXplore: a Cytoscape plugin for visual exploration of hotspot expression in gene regulatory networks"],"prefix":"10.1093","volume":"26","author":[{"given":"Michel A.","family":"Westenberg","sequence":"first","affiliation":[{"name":"1 Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, 2Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, Groningen, 3Department of Genetics, University of Groningen, Haren, 4Center for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Nijmegen, 5 Kluyver Centre for Genomics of Industrial Fermentation, NIZO food research, Ede, 6TI Food and Nutrition, Wageningen and 7Netherlands Bioinformatics Centre, Nijmegen, The Netherlands"}]},{"given":"Jos B.T.M.","family":"Roerdink","sequence":"additional","affiliation":[{"name":"1 Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, 2Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, Groningen, 3Department of Genetics, University of Groningen, Haren, 4Center for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Nijmegen, 5 Kluyver Centre for Genomics of Industrial Fermentation, NIZO food research, Ede, 6TI Food and Nutrition, Wageningen and 7Netherlands Bioinformatics Centre, Nijmegen, The Netherlands"}]},{"given":"Oscar P.","family":"Kuipers","sequence":"additional","affiliation":[{"name":"1 Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, 2Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, Groningen, 3Department of Genetics, University of Groningen, Haren, 4Center for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Nijmegen, 5 Kluyver Centre for Genomics of Industrial Fermentation, NIZO food research, Ede, 6TI Food and Nutrition, Wageningen and 7Netherlands Bioinformatics Centre, Nijmegen, The Netherlands"}]},{"given":"Sacha A.F.T.","family":"van Hijum","sequence":"additional","affiliation":[{"name":"1 Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, 2Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, Groningen, 3Department of Genetics, University of Groningen, Haren, 4Center for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Nijmegen, 5 Kluyver Centre for Genomics of Industrial Fermentation, NIZO food research, Ede, 6TI Food and Nutrition, Wageningen and 7Netherlands Bioinformatics Centre, Nijmegen, The Netherlands"},{"name":"1 Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, 2Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, Groningen, 3Department of Genetics, University of Groningen, Haren, 4Center for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Nijmegen, 5 Kluyver Centre for Genomics of Industrial Fermentation, NIZO food research, Ede, 6TI Food and Nutrition, Wageningen and 7Netherlands Bioinformatics Centre, Nijmegen, The Netherlands"},{"name":"1 Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, 2Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, Groningen, 3Department of Genetics, University of Groningen, Haren, 4Center for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Nijmegen, 5 Kluyver Centre for Genomics of Industrial Fermentation, NIZO food research, Ede, 6TI Food and Nutrition, Wageningen and 7Netherlands Bioinformatics Centre, Nijmegen, The Netherlands"},{"name":"1 Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, 2Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, Groningen, 3Department of Genetics, University of Groningen, Haren, 4Center for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Nijmegen, 5 Kluyver Centre for Genomics of Industrial Fermentation, NIZO food research, Ede, 6TI Food and Nutrition, Wageningen and 7Netherlands 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