{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:12:10Z","timestamp":1773292330909,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2175,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Current challenges in microRNA (miRNA) research are to improve the identification of in vivo mRNA targets and clarify the complex interplay existing between a specific miRNA and multiple biological networks. MiRonTop is an online java web tool that integrates DNA microarrays or high-throughput sequencing data to identify the potential implication of miRNAs on a specific biological system. It allows a rapid characterization of the most pertinent mRNA targets according to several existing miRNA target prediction approaches. It also provides useful representations of the enrichment scores according to the position of the target site along the 3\u2032-UTR, where the contribution of the sites located in the vicinity of the stop codon and of the polyA tail can be clearly highlighted. It provides different graphs of miRNA enrichment associated with up- or down-regulated transcripts and different summary tables about selections of mRNA targets and their functional annotations by Gene Ontology.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.microarray.fr:8080\/miRonTop\/index<\/jats:p>\n               <jats:p>Contact: \u00a0barbry@ipmc.cnrs.fr<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq589","type":"journal-article","created":{"date-parts":[[2010,10,20]],"date-time":"2010-10-20T00:59:01Z","timestamp":1287536341000},"page":"3131-3132","source":"Crossref","is-referenced-by-count":47,"title":["MiRonTop: mining microRNAs targets across large scale gene expression studies"],"prefix":"10.1093","volume":"26","author":[{"given":"Kevin","family":"Le Brigand","sequence":"first","affiliation":[{"name":"1 Centre National de la Recherche Scientifique, Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, UMR6097, 06560 Sophia-Antipolis and 2University of Nice Sophia Antipolis, Nice, France"},{"name":"1 Centre National de la Recherche Scientifique, Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, UMR6097, 06560 Sophia-Antipolis and 2University of Nice Sophia Antipolis, Nice, France"}]},{"given":"Karine","family":"Robbe-Sermesant","sequence":"additional","affiliation":[{"name":"1 Centre National de la Recherche Scientifique, Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, UMR6097, 06560 Sophia-Antipolis and 2University of Nice Sophia Antipolis, Nice, France"},{"name":"1 Centre National de la Recherche Scientifique, Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, UMR6097, 06560 Sophia-Antipolis and 2University of Nice Sophia Antipolis, Nice, France"}]},{"given":"Bernard","family":"Mari","sequence":"additional","affiliation":[{"name":"1 Centre National de la Recherche Scientifique, Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, UMR6097, 06560 Sophia-Antipolis and 2University of Nice Sophia Antipolis, Nice, France"},{"name":"1 Centre National de la Recherche Scientifique, Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, UMR6097, 06560 Sophia-Antipolis and 2University of Nice Sophia Antipolis, Nice, France"}]},{"given":"Pascal","family":"Barbry","sequence":"additional","affiliation":[{"name":"1 Centre National de la Recherche Scientifique, Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, UMR6097, 06560 Sophia-Antipolis and 2University of Nice Sophia Antipolis, Nice, France"},{"name":"1 Centre National de la Recherche Scientifique, Institut de Pharmacologie Mol\u00e9culaire et Cellulaire, UMR6097, 06560 Sophia-Antipolis and 2University of Nice Sophia Antipolis, Nice, France"}]}],"member":"286","published-online":{"date-parts":[[2010,10,19]]},"reference":[{"key":"2023012508032638900_B1","doi-asserted-by":"crossref","first-page":"e9171","DOI":"10.1371\/journal.pone.0009171","article-title":"The DIANA-mirExTra web server: from gene expression data to microRNA function","volume":"5","author":"Alexiou","year":"2010","journal-title":"PLoS One"},{"key":"2023012508032638900_B2","doi-asserted-by":"crossref","first-page":"W323","DOI":"10.1093\/nar\/gkp313","article-title":"GeneSet2miRNA: finding the signature of cooperative miRNA activities in the gene lists","volume":"37","author":"Antonov","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2023012508032638900_B3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature08170","article-title":"Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps","volume":"460","author":"Chi","year":"2009","journal-title":"Nature"},{"key":"2023012508032638900_B4","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1186\/gb-2003-5-1-r1","article-title":"MicroRNA targets in Drosophila","volume":"5","author":"Enright","year":"2003","journal-title":"Genome Biol."},{"key":"2023012508032638900_B5","first-page":"129","article-title":"miRBase: the microRNA sequence database","volume":"342","author":"Griffiths-Jones","year":"2006","journal-title":"Methods Mol. 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Methods"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/26\/24\/3131\/48855437\/bioinformatics_26_24_3131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/26\/24\/3131\/48855437\/bioinformatics_26_24_3131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T08:06:11Z","timestamp":1674633971000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/26\/24\/3131\/288956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,19]]},"references-count":13,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2010,12,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btq589","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,12,15]]},"published":{"date-parts":[[2010,10,19]]}}}