{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T01:45:45Z","timestamp":1764812745633},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The noisy nature of transcriptomic data hinders the biological relevance of conventional network centrality measures, often used to select gene candidates in co-expression networks. Therefore, new tools and methods are required to improve the prediction of mechanistically important transcriptional targets.<\/jats:p>\n               <jats:p>Results: We propose an original network centrality measure, called annotation transcriptional centrality (ATC) computed by integrating gene expression profiles from microarray experiments with biological knowledge extracted from public genomic databases. ATC computation algorithm delimits representative functional domains in the co-expression network and then relies on this information to find key nodes that modulate propagation of functional influences within the network. We demonstrate ATC ability to predict important genes in several experimental models and provide improved biological relevance over conventional topological network centrality measures.<\/jats:p>\n               <jats:p>Availability: ATC computational routine is implemented in a publicly available tool named FunNet (www.funnet.info)<\/jats:p>\n               <jats:p>Contact: \u00a0edi.prifti@crc.jussieu.fr<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq591","type":"journal-article","created":{"date-parts":[[2010,10,20]],"date-time":"2010-10-20T00:59:01Z","timestamp":1287536341000},"page":"3083-3089","source":"Crossref","is-referenced-by-count":24,"title":["Interactional and functional centrality in transcriptional co-expression networks"],"prefix":"10.1093","volume":"26","author":[{"given":"Edi","family":"Prifti","sequence":"first","affiliation":[{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"}]},{"given":"Jean-Daniel","family":"Zucker","sequence":"additional","affiliation":[{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"}]},{"given":"Karine","family":"Cl\u00e9ment","sequence":"additional","affiliation":[{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"}]},{"given":"Corneliu","family":"Henegar","sequence":"additional","affiliation":[{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"},{"name":"1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, F-75006, 2Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris F-75006, 3IRD, UMI 209, UMMISCO, IRD France Nord, Bondy F-93143 and 4Assistance Publique \u2013 H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Nutrition department, Paris F-75013, France"}]}],"member":"286","published-online":{"date-parts":[[2010,10,19]]},"reference":[{"key":"2023012508030618900_B1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2105-5-18","article-title":"Quantifying 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