{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:13:11Z","timestamp":1761559991230},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2118,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Fine-mapping experiments from genome-wide association studies (GWAS) are underway for many complex diseases. These are likely to identify a number of putative causal variants, which cannot be separated further in terms of strength of genetic association due to linkage disequilibrium. The challenge will be selecting which variant to prioritize for subsequent expensive functional studies. A wealth of functional information generated from wet lab experiments now exists but cannot be easily interrogated by the user. Here, we describe a program designed to quickly assimilate this data called ASSIMILATOR and validate the method by interrogating two regions to show its effectiveness.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.medicine.manchester.ac.uk\/musculoskeletal\/research\/arc\/genetics\/bioinformatics\/assimilator\/.<\/jats:p>\n               <jats:p>Contact: \u00a0paul.martin-2@manchester.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq611","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T21:47:07Z","timestamp":1293054427000},"page":"144-146","source":"Crossref","is-referenced-by-count":6,"title":["ASSIMILATOR: a new tool to inform selection of associated genetic variants for functional studies"],"prefix":"10.1093","volume":"27","author":[{"given":"Paul","family":"Martin","sequence":"first","affiliation":[{"name":"Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Barton","sequence":"additional","affiliation":[{"name":"Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Eyre","sequence":"additional","affiliation":[{"name":"Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,12,15]]},"reference":[{"key":"2023012511160476600_B1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat. Methods"},{"key":"2023012511160476600_B2","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/ng.218","article-title":"Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13","volume":"40","author":"Barton","year":"2008","journal-title":"Nat. Genet."},{"key":"2023012511160476600_B3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nature05874","article-title":"Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project","volume":"447","author":"Birney","year":"2007","journal-title":"Nature"},{"key":"2023012511160476600_B4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1126\/science.1105136","article-title":"The ENCODE (ENCyclopedia Of DNA Elements) Project","volume":"306","author":"ENCODE Project Consortium","year":"2004","journal-title":"Science"},{"key":"2023012511160476600_B5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ng.530","article-title":"A map of open chromatin in human pancreatic islets","volume":"42","author":"Gaulton","year":"2010","journal-title":"Nat. Genet."},{"key":"2023012511160476600_B6","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/bioinformatics\/btn564","article-title":"SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap","volume":"24","author":"Johnson","year":"2008","journal-title":"Bioinformatics"},{"key":"2023012511160476600_B7","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res."},{"key":"2023012511160476600_B8","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/ng.403","article-title":"The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer","volume":"41","author":"Pomerantz","year":"2009","journal-title":"Nat. Genet."},{"key":"2023012511160476600_B9","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/nar\/29.1.308","article-title":"dbSNP: the NCBI database of genetic variation","volume":"29","author":"Sherry","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"2023012511160476600_B10","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/ng.2007.32","article-title":"Rheumatoid arthritis association at 6q23","volume":"39","author":"Thomson","year":"2007","journal-title":"Nat. Genet."},{"key":"2023012511160476600_B11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14 000 cases of seven common diseases and 3,000 shared controls","volume":"447","author":"Wellcome Trust Case Control Consortium","year":"2007","journal-title":"Nature"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/27\/1\/144\/48862326\/bioinformatics_27_1_144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/27\/1\/144\/48862326\/bioinformatics_27_1_144.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T11:27:33Z","timestamp":1674646053000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/27\/1\/144\/201776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,15]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btq611","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2011,1,1]]},"published":{"date-parts":[[2010,12,15]]}}}