{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:58:50Z","timestamp":1760853530682},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2122,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Multiple templates can often be used to build more accurate homology models than models built from a single template. Here we introduce PconsM, an automated protocol that uses multiple templates to build protein models. PconsM has been among the top-performing methods in the recent CASP experiments and consistently perform better than the single template models used in Pcons.net. In particular for the easier targets with many alternative templates with a high degree of sequence identity, quality is readily improved with a few percentages over the highest ranked model built on a single template. PconsM is available as an additional pipeline within the Pcons.net protein structure prediction server.<\/jats:p>\n               <jats:p>Availability and implementation: PconsM is freely available from http:\/\/pcons.net\/.<\/jats:p>\n               <jats:p>Contact: \u00a0arne@bioinfo.se<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq664","type":"journal-article","created":{"date-parts":[[2010,12,12]],"date-time":"2010-12-12T01:33:52Z","timestamp":1292117632000},"page":"426-427","source":"Crossref","is-referenced-by-count":12,"title":["Improved predictions by Pcons.net using multiple templates"],"prefix":"10.1093","volume":"27","author":[{"given":"Per","family":"Larsson","sequence":"first","affiliation":[{"name":"Center for Biomembrane Research, Department of Biochemistry and Biophysics, Swedish e-Science Research Centre, Stockholm Bioinformatics Centre, SciLifeLab, Stockholm University SE-10691 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin J.","family":"Skwark","sequence":"additional","affiliation":[{"name":"Center for Biomembrane Research, Department of Biochemistry and Biophysics, Swedish e-Science Research Centre, Stockholm Bioinformatics Centre, SciLifeLab, Stockholm University SE-10691 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Wallner","sequence":"additional","affiliation":[{"name":"Center for Biomembrane Research, Department of Biochemistry and Biophysics, Swedish e-Science Research Centre, Stockholm Bioinformatics Centre, SciLifeLab, Stockholm University SE-10691 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Elofsson","sequence":"additional","affiliation":[{"name":"Center for Biomembrane Research, Department of Biochemistry and Biophysics, Swedish e-Science Research Centre, Stockholm Bioinformatics Centre, SciLifeLab, Stockholm University SE-10691 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,12,11]]},"reference":[{"key":"2023012511545764200_B1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023012511545764200_B2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/prot.10540","article-title":"Combining local-structure, fold-recognition, and new fold methods for protein structure prediction","volume":"53","author":"Karplus","year":"2003","journal-title":"Proteins"},{"key":"2023012511545764200_B3","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1110\/ps.073344908","article-title":"Using multiple templates to improve quality of homology models in automated homology modeling","volume":"17","author":"Larsson","year":"2008","journal-title":"Protein Sci."},{"key":"2023012511545764200_B4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/prot.22476","article-title":"Assessment of global and local model quality in CASP8 using Pcons and ProQ","volume":"77","author":"Larsson","year":"2009","journal-title":"Proteins"},{"key":"2023012511545764200_B5","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1110\/ps.08501","article-title":"Pcons: a neural-network-based consensus predictor that improves fold recognition","volume":"10","author":"Lundstrom","year":"2001","journal-title":"Protein Sci."},{"key":"2023012511545764200_B6","author":"Ray","year":"2010","journal-title":"Improved model quality assessment with proq2."},{"key":"2023012511545764200_B7","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"Sali","year":"1993","journal-title":"J. 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