{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:26:14Z","timestamp":1760577974372},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":2114,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: DNA copy number gains and losses are commonly found in tumor tissue, and some of these aberrations play a role in tumor genesis and development. Although high resolution DNA copy number data can be obtained using array-based techniques, no single method is widely used to distinguish between recurrent and sporadic copy number aberrations.<\/jats:p>\n               <jats:p>Results: Here we introduce Discovering Copy Number Aberrations Manifested In Cancer (DiNAMIC), a novel method for assessing the statistical significance of recurrent copy number aberrations. In contrast to competing procedures, the testing procedure underlying DiNAMIC is carefully motivated, and employs a novel cyclic permutation scheme. Extensive simulation studies show that DiNAMIC controls false positive discoveries in a variety of realistic scenarios. We use DiNAMIC to analyze two publicly available tumor datasets, and our results show that DiNAMIC detects multiple loci that have biological relevance.<\/jats:p>\n               <jats:p>Availability: Source code implemented in R, as well as text files containing examples and sample datasets are available at http:\/\/www.bios.unc.edu\/research\/genomic_software\/DiNAMIC.<\/jats:p>\n               <jats:p>Contact: \u00a0vwalter@email.unc.edu; fwright@bios.unc.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btq717","type":"journal-article","created":{"date-parts":[[2010,12,24]],"date-time":"2010-12-24T03:10:15Z","timestamp":1293160215000},"page":"678-685","source":"Crossref","is-referenced-by-count":27,"title":["DiNAMIC: a method to identify recurrent DNA copy number aberrations in tumors"],"prefix":"10.1093","volume":"27","author":[{"given":"Vonn","family":"Walter","sequence":"first","affiliation":[{"name":"1 Department of Biostatistics, 2Lineberger Comprehensive Cancer Center and 3Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA"},{"name":"1 Department of Biostatistics, 2Lineberger Comprehensive Cancer Center and 3Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA"}]},{"given":"Andrew B.","family":"Nobel","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, 2Lineberger Comprehensive Cancer Center and 3Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA"},{"name":"1 Department of Biostatistics, 2Lineberger Comprehensive Cancer Center and 3Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA"},{"name":"1 Department of Biostatistics, 2Lineberger Comprehensive Cancer Center and 3Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA"}]},{"given":"Fred A.","family":"Wright","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, 2Lineberger Comprehensive Cancer Center and 3Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA"},{"name":"1 Department of Biostatistics, 2Lineberger Comprehensive Cancer Center and 3Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA"}]}],"member":"286","published-online":{"date-parts":[[2010,12,23]]},"reference":[{"key":"2023012511565855900_B1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ng1215","article-title":"Chromosome aberrations in cancer","volume":"34","author":"Albertson","year":"2003","journal-title":"Nat. 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